中华皮肤科杂志 ›› 2003, Vol. 36 ›› Issue (8): 439-440.

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近平滑念珠菌性皮肤肉芽肿首例报告

张怀亮, 吕桂霞, 林彤, 曾学思, 李岷, 李阿梅   

  1. 中国医学科学院、中国协和医科大学皮肤病医院 南京 210042
  • 收稿日期:2002-08-02 出版日期:2003-08-15 发布日期:2003-08-15

Skin Granuloma Caused by Candida parapsilosis:A First Case Report in China

ZHANG Huai-liang, LÜ Gui-xia, LIN Tong, ZENG Xue-si, LI Min, LI A-mei   

  1. Institude of Dermatology, Chinese Academy of Medical Sciences&Peking Union Medical College, Nanjing 210042, China
  • Received:2002-08-02 Online:2003-08-15 Published:2003-08-15

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摘要： 目的 报告1例首见近平滑念珠菌性皮肤肉芽肿。方法 临床检查排除其他疾病,皮损表面痂皮多次真菌培养、镜检、菌种鉴定分析,皮损组织病理切片及特殊病理染色证实为近平滑念珠菌所致斑块性肉芽肿;用联合抗真菌药物治疗。结果 患者左面部8cm×10cm大小浸润性斑块,表面密布增厚性焦痂,痂皮镜检及特殊PAS染色均见有大量的真菌孢子;病理活检,真皮内有大量淋巴细胞和浆细胞浸润团块,皮损培养多次均为近平滑念珠菌生长,经氟康唑联合伊曲康唑治疗2个月,镜检转阴,皮损基本控制。

关键词: 念珠菌病, 肉芽肿, 念珠菌属

Abstract: Objective To report a case of skin granuloma caused by Candida parapsilosis which is firstly described in China.Methods The patient was given overall clinical examinations to exclude other diseases.The lesional crust samples were taken for culture and microscopy repeatedly.At the same time histopathology with special staining was performed.The patient was treated with combined antifungal agents.Results There was a 8cm×10cm infitrating plaque covered with thick crusts on the left side of the patient's face.Large quantities of fungal spores were found in the crust by microscopy,and by PAS staining as well.Histopathology showed an intensive intradermal infiltration of lymphocytes and plasma cells.Culture of specimens taken from skin lesions identified as Candida parapsilosis.After two months of combination therapy of fluconazole and itraconazole,the lesion gradually subsided.The patient was still being treated with above antifungal drugs.

Key words: Candidiasis, Granuloma, Candida