手术后放疗加口服积雪甙治疗瘢痕疙瘩的临床研究

中华皮肤科杂志 ›› 2003, Vol. 36 ›› Issue (6): 342-344.

手术后放疗加口服积雪甙治疗瘢痕疙瘩的临床研究

赵亮, 方方, 王焱, 吴信峰, 王强, 陈晓栋, 龚向东, 张国成

中国医学科学院、中国协和医科大学皮肤病研究所南京 210042

收稿日期:2002-03-07 出版日期:2003-06-15 发布日期:2003-06-15

Treatment of Keloid with Centella Tripterpenes After Surgical Excision and X-Ray Irradiation

ZHAO Liang, FANG Fang, WANG Yan, WU Xin-feng, WANG Qiang, CHEN Xiao-dong, GONG Xiang-dong, ZHANG Guo-cheng

Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, China

Received:2002-03-07 Online:2003-06-15 Published:2003-06-15

摘要/Abstract

摘要： 目的比较3种联合疗法治疗瘢痕疙瘩的效果,同时探讨积雪甙对瘢痕疙瘩的治疗作用。方法在外科手术切除术后予以浅层X线放疗的基础上,将106例瘢痕疙瘩患者随机分成使用积雪甙的高剂量组和低剂量组,以及使用安慰剂的对照组进行研究。结果所有患者手术切口均甲级愈合,使用积雪甙的治疗组75例患者痊愈率33.3%,有效率86.7%;对照组31例患者的痊愈率12.9%,有效率48.4%。Ridit方法分析:2个治疗组疗效明显优于使用安慰剂的对照组(P<0.01和P<0.05),而使用积雪甙片的2个治疗组之间差异无显著性(P>0.05)。结论手术、放射结合积雪甙片治疗瘢痕疙瘩效果可靠,且无明显的副作用。

关键词: 瘢痕疙瘩, 积雪草

Abstract: Objective To validate the therapeutic effect of Centella Triterpenes after surgical excision and X-ray irradiation.Methods Surgical excision was performed on one hundred and six patients with keloid,after operation superficial X-ray irradiation was given to the patients.Then,they were divided into three groups:36 cases in group A treated with higher dose of Centella Triterpenes;39 cases in group B treated with lower dose of Centella Triterpenes;31 cases took placebo as controls.All patients were followed up for 12 months after treatment.Results All patients were healed completely after operation.The effective rate was significantly higher in Centella Triterpenes groups than that in the control group(P<0.01).No significant difference was found between the effective rates of group A and group B.Conclusions Combination therapy with centella Triterpenes surgical operation and superficial X-ray irradiation is effective in treating keloid with mild adverse reactions.

Key words: Keloid, Centella Triterpenes Tablets

赵亮, 方方, 王焱, 吴信峰, 王强, 陈晓栋, 龚向东, 张国成. 手术后放疗加口服积雪甙治疗瘢痕疙瘩的临床研究[J]. 中华皮肤科杂志, 2003, 36(6): 342-344.

ZHAO Liang, FANG Fang, WANG Yan, WU Xin-feng, WANG Qiang, CHEN Xiao-dong, GONG Xiang-dong, ZHANG Guo-cheng. Treatment of Keloid with Centella Tripterpenes After Surgical Excision and X-Ray Irradiation[J]. Chinese Journal of Dermatology, 2003, 36(6): 342-344.

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