江苏、安徽籍汉族天疱疮患者HLA-DR基因的相关性研究

摘要/Abstract

摘要： 目的探讨HLA-DR位点基因在天疱疮易感性中的作用。方法用序列特异性引物-聚合酶链反应(PCR-SSP)方法,对61例寻常型天疱疮(PV)、37例红斑型天疱疮(PE)患者及57例正常对照者进行了HLA-DR等位基因的分型,并分析了DR基因在两组中的分布。结果与正常对照组比较,PV患者组DR4、DRB1*14(*1401、*1404、*1405)基因频率明显增高,校正P值分别为<0.05及<0.01;PE患者组DR4、DRB1*14基因频率比对照组也显着增高,校正P值<0.05.对DR4阳性标本的组内基因亚型分型结果发现,PV组中DRB1*0403、DRB1*0406频率显着增高,校正P值<0.05;PE中DRB1*0406频率显着增高,校正P值<0.05.结论本研究结果提示,DR4、DRB1*14基因可能是PV和PE的易感基因;HLA-DR基因在PV和PE的易感性方面所起的作用可能相似。

关键词: 天疱疮, HLA-DR抗原

Abstract: Objective To investigate the predisposing alleles of HLA-DR genes in pemphigus. Methods Polymerase chain reaction-specific sequence primers (PCR-SSP) method was applied to type HLA-DR subregion in the patients with pemphigus vulgaris (PV), pemphigus erythematosus (PE) and matched control subjects of Han nationality from Jiangsu and Anhui provinces. Results The results demonstrated that DR4, DRB1*14 (*1401, *1404,*1405)gene frequencies were significantly higher in both PV(Pc<0.05 and <0.01 respectively)and PE patients (Pc<0.05) than those in controls. The gene frequencies of DRB1*0406 were significantly increased in PV and PE patients (Pc<0.05), which was demonstrated by further typing of DR4 positive specimens. DRB1*0403 was also increased in PV patients (Pc<0.05) compared with controls. Conclusions The results suggest that HLA-DR4, DRB1*14 genes might be the susceptible genes and they may play a similar role in the susceptibility of PV and PE.

Key words: Pemphigus, HLA-DR antigens

周淑华, 林麟, 靳培英, 叶顺章. 江苏、安徽籍汉族天疱疮患者HLA-DR基因的相关性研究[J]. 中华皮肤科杂志, 2002, 35(1): 13-16.

ZHOU Shuhua, LIN Lin, JIN Peiying, YE Shunzhang . Association of HLA-DR Genes in Jiangsu and Anhui Chinese Patients with Pemphigns[J]. Chinese Journal of Dermatology, 2002, 35(1): 13-16.

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