中华皮肤科杂志 ›› 2001, Vol. 34 ›› Issue (6): 435-436.

• 论著 • 上一篇    下一篇

22种抗菌消炎中药有效成分对痤疮丙酸杆菌的抑制作用

夏明静1, 曹煜1, 杨捷1, 吴承龙2   

  1. 1. 贵阳医学院附属医院皮肤科 550004;
    2. 贵阳医学院微生物学教研室
  • 收稿日期:2000-12-19 出版日期:2001-12-15 发布日期:2001-12-15

Inhibition of Propionibacterium acnes by Effective Components of Traditional Chinese Medicines

XIA Mingjing1, CAO Yu1, YANG Jie1   

  1. Department of Dermatology, Affiliated Hospital of Guiyang Medical College, Guiyang 550001, China
  • Received:2000-12-19 Online:2001-12-15 Published:2001-12-15

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摘要： 目的 22种抗菌消炎中药有效成分对痤疮丙酸杆菌(P.acne,Propionibacterium acne)的抑制作用。方法 进行22种中药有效成分药敏实验。结果 丁香酚、桉叶素对P.acne具有高敏作用;黄芩甙、大黄素等10种药物对P.acne具有中敏作用;油镜下观察发现,抑制P.acne后较抑制前细菌数量/单位面积明显减少,大部分细菌溶解死亡,失去正常形态。结论 丁香酚、桉叶素和其它中药有效成分对P.acne具有体外抑制作用。

关键词: 微生物敏感性试验, 中草药, 丙酸杆菌,痤疮

Abstract: Objective To investigate the inhibitory effects of Propionibacterium acnes (P.acnes) by 22 effective components of traditional Chinese medicines. Methods The susceptibility tests of P.acnes to 22 effective components of traditional Chinese medicines were performed. Results P.acnes was highly sensitive to both eugenol and cineole, and moderately sensitive to baicalin, emodin and others. The number of bacteria per oil field decreased obviously under microscopy and bacteriolysis was found after the treatment with those components. Conclusion Eugenol, cineole and other components of traditional Chinese medicines can inhibit P.acnes in vitro.

Key words: Propionibacterium acnes, Microbial sensitivity tests, Medicine herbs(TCD)