中华皮肤科杂志 ›› 2001, Vol. 34 ›› Issue (6): 437-438.

• 论著 • 上一篇    下一篇

季节性接触性皮炎患者白介素4水平与血清总IgE含量的关系

刘彦群, 何静   

  1. 江苏省徐州医学院第一附属医院皮肤科 221002
  • 收稿日期:2001-03-14 出版日期:2001-12-15 发布日期:2001-12-15

Study on the Relationship Between the Levels of IL-4 and Total Serum IgE in Patients with Seasonal Contact Dermatitis

LIU Yanqun, HE Jing   

  1. Department of Dermatology, First Affiliated Hospital, Xuzhou Medical College, Xuzhou, Jiangsu 221002, China
  • Received:2001-03-14 Online:2001-12-15 Published:2001-12-15

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摘要： 目的 研究季节性接触性皮炎患者血清总IgE产生与白介素4(IL-4)水平的关系。方法 用三抗体免疫放射测定法(IRMA)检测了29例季节性接触性皮炎患者和35例非季节性接触性皮炎患者血清总IgE水平;用ELISA法检测外周血单一核细胞体外培养在PHA诱导后IL-4的分泌,并以24例正常人做对照。结果 季节性接触性皮炎患者的IL-4水平增高(P<0.01),且血清总IgE水平高于正常对照(P<0.01).IL-4水平与血清总IgE水平呈高度正相关(r=0.96,P<0.001).结论 季节性接触性皮炎的发病机理可能不同于非季节性接触性皮炎,其血清总IgE的增高可能与IL-4水平增加有关。

关键词: 皮炎,接触性, 白细胞介素4, IGE

Abstract: Objective To investigate the relationship between the levels of total serum IgE and IL-4 in patients with seasonal contact dermatitis. Methods Total serum IgE was tested by immunoradiometric assay(IRMA) in 29 cases of seasonal contact dermatitis, 35 cases of allergic contact dermatitis and 24 cases of healthy controls. Production of IL-4 was detected by ELISA from peripheral blood mononuclear cells (PBMC) cultured with PHA for 48 hours. Results The levels of IL-4 secreted by PBMC and total serum IgE were significantly higher in patient with seasonal contact dermatitis than those in control group (P<0.01 and P<0.01, respectively). Significant positive correlation was noticed between the levels of IL-4 and total serum IgE (r=0.96,P<0.001). Conclusion The immunopathology of seasonal contact dermatitis might differ from that of non seasonal contact dermatitis. The increased level of total serum IgE might be associated with the increased IL-4 secretion.

Key words: Dermatitis,contact, Interleukin 4, IGE