中华皮肤科杂志 ›› 2001, Vol. 34 ›› Issue (5): 358-360.

• 论著 • 上一篇    下一篇

长穗离蠕孢引起暗色丝孢霉病一例

吕桂霞1, 沈永年1, 陈伟1, 秦春玲2, 刘维达1, 吴绍熙1   

  1. 1. 中国医学科学院、中国协和医科大学皮肤病研究所, 南京 210042;
    2. 广州军区广州总医院
  • 收稿日期:2000-09-30 出版日期:2001-10-15 发布日期:2001-10-15

Phaeohyphomycosis Caused by Bipolaris Spicifera:First Case Report in China

LU Guixia1, SHEN Yongnian1, CHEN Wei1   

  1. Institute of Dermatology, Chinese Acadamy of Medical Sciences, Peking Union Medical College, Nanjing 210042, China
  • Received:2000-09-30 Online:2001-10-15 Published:2001-10-15

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摘要： 目的 分离和鉴定1株引起颅内感染的罕见病原菌.方法 从患者脑脊液取材、涂片及培养,并经小鼠致病性研究重现组织病理学特征.结果 根据直接镜检和培养的菌落形态及显微镜下分生孢子的大小、排列及芽管形成的位置等特征,鉴定为长穗离蠕孢,并经动物试验证实其致病性.在小鼠脑组织标本中可见菌丝及类似厚壁孢子的肿胀细胞,菌丝分隔且有色素,与暗色丝孢霉病相符.结论 该病例为国内首报的由长穗离蠕孢引起的暗色丝孢霉病,其致病力强,预后不良.

关键词: 长穗离蠕孢, 暗色丝孢霉病

Abstract: Objective To isolate and identify pathogenic fungus in a patient with intracranial infection.Methods Specimens were taken from the spinal fluid of the patient.Then,microscopy and fungal culture were done to identify the pathogen.The histopathologic features were reprod uced through animal pathogenicity study in a nice model.Results According to the colony appearance in culture medium,the morphological features in microscopy,such as conidia arrangement and size,germtube forming site,this fungus was identified as Bipolaris spicifera.Hyphae and swollen hyphal cells resembling chlamydospores,septate pigmented hyphae were observed in braintissue specimen of mice experimental model,which were consistent with phaeohyphomycosis.Conclusion This is the first case of phaeohyphomycosis caused by Bipolaris spicifera reported in China.

Key words: Bipolaris spicifera, Phaeohyphomycosis