中华皮肤科杂志 ›› 2001, Vol. 34 ›› Issue (4): 268-270.

• 论著 • 上一篇    下一篇

白癜风患者血清中抗黑素细胞膜表面抗原自身抗体的检测

李志强1, 高天文2, 赵小东2, 陈金穆2, 刘荣卿1   

  1. 1. 第三军医大学西南医院皮肤科 重庆市 400038;
    2. 第四军医大学西京医院皮肤科
  • 收稿日期:2000-09-06 出版日期:2001-08-15 发布日期:2001-08-15
  • 基金资助:
    国家教委留学归国人员启动基金课题(97001)

Detection of Auto Antibodies to Melanocyte Surface Antigen in Sera of Patients with Vitiligo

LI Zhiqiang1, GAO Tianwen2, ZHAO Xiaodong2   

  1. Department of Dermatology, Xinan Hospital, The Third Military Medical University, Chongqing 400038, China
  • Received:2000-09-06 Online:2001-08-15 Published:2001-08-15

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摘要： 目的 检测白癜风患者血清中的抗黑素细胞抗体并分析其与疾病活动性及亚型之间的关系。方法 采用体外培养的正常人黑素细胞,使用活细胞ELISA检测了334例不同亚型及病期的白癜风患者血清中抗黑素细胞膜表面抗原IgG自身抗体。结果 活动期寻常型白癜风患者血清有67%检出抗黑素细胞IgG抗体,稳定期寻常型白癜风患者IgG抗黑素细胞抗体阳性率为30.3%;活动期节段型白癜风阳性率为40.54%,稳定期节段型白癜风的阳性率为21.42%。活动期寻常型白癜风患者血清中抗黑素细胞IgG抗体水平明显高于稳定期寻常型白癜风、活动期节段型白癜风患者及正常人;活动期节段型白癜风患者抗黑素细胞水平亦明显高于正常人。结论 白癜风患者体内广泛存在抗黑素细胞自身抗体,自身免疫机制可能在寻常型和节段型的发病中起一定作用。

关键词: 白癜风, 黑素细胞

Abstract: Objective To detect circulating autoantibodies to melanocytes in patients with vitiligo and its relationship to disease activity and subtypes. Methods IgG autoantibodies to melanocyte surface antigens were measured in sera from 334 patients with vitiligo and 50 normal individuals using a live cell enzyme linked immunoabsorbent assay. Results Anti melanocyte IgG antibody was present in 67% of patients(165/250) with active non segmental vitiligo, 30.3% of patients(10/33) with inactive non segmental vitiligo, 40.54% of patients(23/51) with active segmental vitiligo and 21.42% of patients with inactive segmental vitiligo (3/14). The autoantibody levels were significantly higher in patients with active non segmental vitiligo and active segmental vitiligo than those with inactive disease or normal individuals. Conclusion Autoimmune mechanism may play an important role in both non segmental and segmental vitiligo.

Key words: Vitiligo, Melanocyte