中华皮肤科杂志 ›› 2001, Vol. 34 ›› Issue (2): 122-123.

• 论著 • 上一篇    下一篇

皮质类固醇对二期显性梅毒外周血T淋巴细胞及其预后的影响

周平玉, 廖康煌, 徐明, 王侠生   

  1. 上海医科大学华山医院皮肤科 200040
  • 收稿日期:2000-05-22 出版日期:2001-04-15 发布日期:2001-04-15

Influence of Corticosteroid on Peripheral Blood Lymphocyte in Secondary Syphilis and Prognosis of Syphilis

ZHOU Pingyu, LIAO Kanghuang, XU Ming   

  1. Department of Dermatology, Huashan Hospital, Shanghai Medical University, Shanghai 200040, China
  • Received:2000-05-22 Online:2001-04-15 Published:2001-04-15

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摘要： 目的 了解皮质类固醇对二期显性梅毒患者外周血T淋巴细胞及其预后的影响。方法 用流式细胞仪对11例用皮质类固醇的二期显性梅毒患者及20例对照的外周血淋巴细胞进行检测,并分别于治疗后的15d及3、6、9、12个月,随访两组梅毒患者的皮损及快速血浆反应素试验(RPR)情况。结果 11例应用皮质类固醇的梅毒患者其外周血CD3+、CD4+显著低于未用皮质类固醇的对照组;其皮损的消退及RPR转阴率在3个月内显著低于对照组。结论 皮质类固醇可使二期梅毒患者的外周血CD3+、CD4+下降,从而影响梅毒患者近期皮损的消退及快速血浆反应素试验转阴率。

关键词: 梅毒, 糖皮质激素类, T淋巴细胞, 预后

Abstract: Objective To investigate if corticosteroid could influence peripheral blood CD3+、 CD4+ and CD8+ cells in secondary syphilis and the prognosis of syphilis. Methods CD3+、 CD4+、 CD8+ cells were detected in 11 patients who took corticosteroid and 20 patients who did not. The effects on the therapeutic effect of lesions were observed. Results The levels of CD3+ and CD4+ in peri pheral blood were significantly lower in corticosteroid group than those in controls. The proportion of patients whose RPR test turned to negative and lesions cured was significantly lower in corticosteroid group than those in controls with in the first three months after treatment. Conclusion Corticosteroid administration decreases the levels of CD3+ and CD4+ in secondary syphilis and therefore influence the prognosis of syphilis.

Key words: Syphilis, Glucocorticoids, T-lymphocytes, Prognosis