中华皮肤科杂志 ›› 2000, Vol. 33 ›› Issue (6): 386-388.

• 论著 • 上一篇    下一篇

白术等对UVB诱导豚鼠皮肤色素沉着的抑制作用

李洪武1, 朱文元1, 夏明玉2   

  1. 1. 南京医科大学第一附属医院皮肤科 210029;
    2. 南京医科大学电镜室 210029
  • 收稿日期:1999-12-17 出版日期:2000-12-15 发布日期:2000-12-15
  • 基金资助:
    国家自然科学基金资助课题(39570658)

Inhibitory Effects of Ethanol Extracts Obtained from Five Traditional Chinese Medicines on Experimental Hypermelanosis Induced by UVB Using a Brownish Guinea Pig Model

LI Hongwu1, ZHU Wenyuan1, XIA Mingyu2   

  1. Department of Dermatology, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029
  • Received:1999-12-17 Online:2000-12-15 Published:2000-12-15

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摘要： 目的 研究中药对皮肤色素沉着的抑制作用,筛选有作用的单味中药,为应用中药治疗色素障碍性皮肤病提供实验依据。方法 选定体外对酪氨酸酶活性有显著抑制作用的中药5味,应用棕黄色豚鼠UVB照射诱导皮肤色素沉着实验动物模型,采用HE、Schmorl、Imokawa等方法染色,观察外用中药后黑素细胞数量和形态的改变。结果 白术、茯苓、山茱萸、猪苓、沙苑蒺藜等中药组多巴阳性黑素细胞数及含黑素颗粒细胞数较对照组明显减少(P<0.01),其中白术、茯苓、山茱萸与阳性对照组3%氢醌外用差异无显著性(P>0.05)。结论 白术、茯苓、山茱萸、猪苓、沙苑蒺藜等中药对UVB诱导的色素沉着具有抑制作用。

关键词: 白术, 沙苑子, 山茱萸, 猪苓, 茯苓, 皮肤色素沉着, 一元酚单氧酶

Abstract: Objective To investigate the inhibitory effects of traditional Chinese medicine (TCM) on hypermelanosis and provide experimental evidence for treating skin pigmentary disorders. Methods Five TCMs with strong inhibitory effects on tyrosinase activity were tested. The changes of the number and morphology of melanocytes induced by UVB were observed in the experimental hypermelanosis model (brownish guinea pig). Results Decreased melanocytes and melanin granules were found with the treatment of Poria cocos, Polyporus umbellatus, Cornus officinalis Sieb. et Zucc., Atractylodes macrocephala Koidz., Astoagalus complanatus R. Br. ex Bge. Conclusion There are inhibitory effects on hypermelanosis induced by UVB with the treatment of Poria cocs, Polyporus umbellatus, Cornus officinalis Sieb.et Zucc., Atractylodes macrocephala Koidz., Astoagalus complanatus R. Br.ex Bge.

Key words: Atractylodes macrocephala, Astrogalus complanatus, Cornus officinalis, Polyporus umbellatus, Poria cocos, Skin pigmentation, Monophenol monooxygenase