中华皮肤科杂志 ›› 2000, Vol. 33 ›› Issue (5): 336-337.

• 论著 • 上一篇    下一篇

多形红斑与HLA相关性研究

姜海燕, 宋芳吉, 翟宁, 肖毅   

  1. 中国医科大学第一临床医院皮肤科, 沈阳110001
  • 收稿日期:1999-12-22 出版日期:2000-10-15 发布日期:2000-10-15

Study on the Association Between HLA and Erythema Multiforme

JIANG Haiyan, SONG Fangji, ZHAI Ning   

  1. Department of Dermatology, The First Hospital, China Medical University, Shenyang 110001
  • Received:1999-12-22 Online:2000-10-15 Published:2000-10-15

PDF

78

赞

摘要： 目的 研究多形红斑与HLA相关性。方法 采用血清学技术和聚合酶链式反应-序列特异性引物技术,检测多形红斑患者HLAⅠ类抗原和HLAⅡ类基因。结果 在30例多形红斑患者中,HLA-A30+31、B13抗原频率较对照组明显增高(A30+31:Pc<0.01,RR=6.64;B13:Pc<10-3,RR=7.88)。HLA-DQB1*04基因频率在多形红斑患者较正常人对照组明显增高(DQB1*04:Pc<10-3,RR=4.8125),而HLA-DQB1*03基因频率较正常人对照组明显降低(DQB1*03:Pc<10-5,RR=0.07)。结论 多形红斑与HLA-A30+31、B13、DQB1*04呈正相关,与HLA-DQB1*03呈负相关。

关键词: 红斑,多形, HLA抗原, 聚合酶链反应

Abstract: Objective To investigate the association of erythema multiforme(EM) with HLA. Methods ClassⅠ HLA antigen was detected by serology and classⅡ HLA gene typing was performed by PCR-SSP method, thirty patients with EM were detected. Results The frequency of HLA-A30+31 and HLA-B13 antigen was significantly higher in EM patients than that in the controls(A30+31:Pc<0.01,RR=6.64;B13:Pc<10-3,RR=7.88).The frequency of HLA-DQB1*04 gene was markedly higher in patients than that in the controls (DQB1*04: Pc<10-3,RR=4.8125),while the frequency of DQB1*03 gene was significantly lower in EM patients than that in the controls(DQB1*03:Pc< 10-5,RR=0.07). Conclusion There is a positive correlation between EM and HLA-A30+31、B13、DQB1*04,with a negative correlation between EM and HLA-DQB1*03.

Key words: Erythema multiforme, HLA antigens, Polymerase chain reaction