中华皮肤科杂志 ›› 1999, Vol. 32 ›› Issue (5): 297-299.

• 论著 • 上一篇    下一篇

SLE并发鼻疽诺卡菌感染引起皮下及脑脓肿一例

席丽艳1, 鲁长明1, 曾凡钦1, 陈伟雄1, 三上襄2   

  1. 1. 中山医科大学孙逸仙纪念医院皮肤科 广州 510120;
    2. 日本千叶大学医学真菌研究中心
  • 收稿日期:1999-01-26 修回日期:1999-03-29 出版日期:1999-10-15 发布日期:1999-10-15

Subcutaneous and Brain Abscesses Caused by Nocardia farcinica Infection in a Patient with Systemic Lupus Erythematosus

XI Liyan1, LU Changming1, ZENG Fanqin1   

  1. Department of Dermatology, Sun Yat Sen Memorial Hospital, Sun Yat Sen Medical University, Guangzhou 510120
  • Received:1999-01-26 Revised:1999-03-29 Online:1999-10-15 Published:1999-10-15

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摘要： 目的 探讨一例SLE患者脑脓肿及皮下脓肿的病原菌.方法 从患者脑脊液和皮下脓肿取材,涂片Gram染色并培养.结果 涂片Gram染色阳性,培养菌落类似星形诺卡菌,但在生化特性方面略有不同:抗酸性为阳性,尿素酶阳性,不分解酪氨酸、黄嘌呤,能发酵葡萄糖、鼠李糖、赤藓糖.可在 45℃生长,确证为鼻疽诺卡菌并证实此分离菌株对多种药物耐药.小鼠动物实验证明它可引起多发性脑脓肿.结论 鼻疽诺卡菌有致病性,多重耐药性,毒力强,尤其在SLE患者可致严重后果.

关键词: 红斑狼疮, 系统性, 鼻疽诺卡菌

Abstract: Objective To study the pathogens of subcutaneous and brain abscesses in a patient with SLE.Methods Specimens were taken from the leg abscess and spinal fluid of the patient.Then,smear,Gram's stain and culture were done to identify the pathogen.Results A strain of Nocardia farcinica was isolated,which was Gram's positive The colony was very similar to that of Nocardia asteroides in morphology and physiological characteristics,with a little difference in biochemical characteristics.N.Farcinica grew at 45℃;produced acid from glucose,rhamnose,or erythritol;did not decompose tyrosine and xanthine.It was acid fast and hydrolyzed urea.The strain was multi-drug-resistant and could cause multi-abscesses in mice.Conclusion N.Farcinica is pathogenic,virulent and multi drug resistant,and could cause severe outcome,especially in SLE patients.

Key words: Lupus erythematosus,systemic, Nocardia farcinica