中华皮肤科杂志 ›› 1998, Vol. 31 ›› Issue (6): 368-370.

• 论著 • 上一篇    下一篇

青蒿琥酯对Ⅰ～Ⅳ型变态反应的影响

张汝芝, 高玉祥   

  1. 安徽蚌埠医学院附属医院皮肤科 233004
  • 收稿日期:1997-09-26 修回日期:1998-04-20 出版日期:1998-12-15 发布日期:1998-12-15

Effect of Artesunate on Ⅰ～Ⅳ Types of Hypersensitivity

Zhang Ruzhi, Gao Yuxiang   

  1. Department of Dermatology, Bengbu Medical College, Anhui 233004
  • Received:1997-09-26 Revised:1998-04-20 Online:1998-12-15 Published:1998-12-15

PDF

319

赞

摘要： 目的 研究青蒿琥酯对过敏反应的作用 方法 分别建立Ⅰ、Ⅲ、Ⅳ型过敏反应的动物模型.腹腔注射青蒿琥酯100～125mg·kg-1·d-1, 连续6天, 观察实验动物的反应, 设立体外溶血反应体系, 加入一定浓度的青蒿琥酯, 测定其抑制作用 结果 青蒿琥酯15mg·kg-1·d-1腹腔注射、抑制Wistar大鼠的被动皮肤过敏反应(P<0.01)及Arthus反应(P<0.05), 100mg·kg-1·d-1腹腔注射, 减轻小鼠迟发型过敏反应中足肿胀及炎性细胞浸润, 试管内浓度3.10×10-5mol/L时抑制体外溶血(P<0.05) 结论 青蒿琥酯明显抑制Ⅰ～Ⅳ型过敏反应.

关键词: 超敏反应, 青蒿琥酯

Abstract: Objective To investigate the effeets on allergic reaction.Methods Following reactions were used for the study:(l)passive cutaneous anaphylaxis in rats:(2)systems of hemolysis in ht with complement:(3)Arthus phenomennon in rats:(4)delaved palmopantar swelling indueed by SRBC in mice.Results(1)a marked suppressive, efeel of Artesuate on PCA.the inhibition rate was 33.3%:(2) Artesunate at the coneentration of l.30×l0-3mol/L deoressed hemolvsis in vitro:(3)at dose of 125mg·kg-1·d-1Artesunate inhihited Arthus phenomenon in rats(compared with control group P<0.01):(4)the palmoplantar swelling and pathotogic changes of DTH in mice was decreased by Artesunate.ip 100mg·kg-1·d-1 Conclusion Artesunate markedly inhibits Ⅰ～Ⅳ lypes of allergic reaction, and offer a novelreatment for allergic diseases and immune-mediated disorders.

Key words: Hypersensitivity, Artesunate