中华皮肤科杂志 ›› 1997, Vol. 30 ›› Issue (1): 19-20.

• 论著 • 上一篇    下一篇

斑秃患者白介素1受体拮抗剂基因多态性研究

张军民, 唐玉珠, 许彤华, 刘贞富, 张德美, 杨琦   

  1. 同济医科大学附属协和医院皮肤科, 武汉 430022
  • 收稿日期:1996-05-23 修回日期:1996-08-20 出版日期:1997-02-15 发布日期:1997-02-15

Study of Interleukin-1 Receptor Antagonist Gene Polymorphism in Alopecia Areata

Zhang Junming, Tang Yuzhu, Xu Tonghua   

  1. Department of Dermatology, the Union Hospital, Tongji Medical University, Wuhan 430022
  • Received:1996-05-23 Revised:1996-08-20 Online:1997-02-15 Published:1997-02-15

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摘要： 斑秃是与遗传相关的多因素皮肤炎症性疾病.白介素1及其受体拮抗剂在皮肤炎症反应中起重要作用,白介素1受体拮抗剂基因呈多态性.本研究旨在探讨其多态性在斑秃发病机理中的作用.采用聚合酶链反应方法研究了72例斑秃患者和130例正常对照者的白介素1受体拮抗剂基因型.结果: 斑秃患者A2频率显著高于正常人.提示白介素1受体拮抗剂基因中A2可能在斑秃的病损严重度方面起作用.

关键词: 斑秃, 受体,白介素1, 基因

Abstract: Alopeeia areata (AA) has been well recognized with familial tendencies, but the genetic basis of this clinical observation remains unknown. The cytokine interleukin-1 receptor antagonist (ILlra) is a potent antiinflammatory protein that can prevent immunemediated inflammatory response in the skin. We characterized a polymorphism within the gene for this cytokine ILlra in this study and tested the gene as a possible marker in patients with alopecia areata. We have determined allele frequencies of the polymorphic cytokine genes in a control population and a group of 72 patients with alopecia areata. The frequency of allele 2 of interleukin-1 receptor antagonist in patients with AA was significantly higher than that of control group. It suggests that interleukin-1 receptor antagonist gene may be a candidate gene or severity factor for alopecia areata.

Key words: Alopecia,areata, Receptors,interleukin-1, Gene