中华皮肤科杂志 ›› 1996, Vol. 29 ›› Issue (4): 2367-239.

• 论著 • 上一篇    

SLE血小板聚集功能及茶黄烷醇类物质对其影响

徐根波, 李翠琴, 王世炅, 孙国均   

  1. 浙江医科大学附属第二医院 杭州 310009
  • 收稿日期:1995-08-22 修回日期:1995-12-22 出版日期:1996-08-15 发布日期:1996-08-15

The Function of Platelet Aggregation in SLE and the Efect of Tea Flavanols

Xu Genbo, Li Cuiqin, Wang Shijiong   

  1. The Second Affiliated Hospital, Zhejiang Medical University, Hangzhou 310009
  • Received:1995-08-22 Revised:1995-12-22 Online:1996-08-15 Published:1996-08-15

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摘要： 60例SLE患者血小板自发聚集率和花生四烯酸、二磷酸腺苷诱导的聚集率较正常人明显升高(P<0.01),尤以活动期、伴肾损害和补体下降者为甚.血小板自发聚集率与循环免疫复合物增高呈正相关,提示其可作为SLE患者高凝状态的观察指标之一.茶黄烷醇类物质能抑制各种诱导剂诱导的SLE患者血小板的聚集,且随着浓度增加而增加,并能提高聚集后血浆环磷酸腺苷水平,提示茶黄烷醇类物质可能作用于前列腺素代谢的中间环节,对SLE伴高凝状态的治疗具有一定价值.

关键词: 红斑狼疮.系统性, 血小板凝集, 茶黄烷醇类物质

Abstract: The rate of platelet spontaneous aggregation and the rate of aggregation induced by arachidonic acid(AA),and adenosine diphosphate(ADP) in 60 patients with SLE were significantly higher than those in controls (P<0.01),especialy in those of progresive stage,with renallesion and hypocomplementemia.Platelet spontaneous aggregation rate was positively correlated with increased CIC which suggests that the spontaneous aggregation rate could be used as one of the indexes for hypercoagulation state in SLE.Inaddition,it was found that tea flavanols could inhibit platelet aggregation induced by ADP,adrenaline and AA in patients with SLE.The efect of tea flavanols increased with increasing concentrations,and could increase plasm a cAMP level after platelet aggregation.It suggests that tea flavanols may exert an action on the metabolic link in prostaglandins,and be of value for the treatment of SLE patients complicated with hypercoagulation state.

Key words: Lupus erythematosus,systemic, Platelet aggregation, Tea flavanols