中华皮肤科杂志 ›› 1996, Vol. 29 ›› Issue (1): 45-47.

• 论著 • 上一篇    下一篇

转移抑制基因nm23在恶性黑素瘤中的表达

刘丹亚1, 苏宝山2, 徐汉卿1, 陈学民3   

  1. 1. 西安医科大学第二附属医院皮肤科, 710004;
    2. 西安医科大学第二附属医院病理科;
    3. 西安医科大学第一附属医院内科
  • 收稿日期:1995-06-19 修回日期:1995-09-25 出版日期:1996-02-15 发布日期:1996-02-15

Expression of Matastatic Suppressor Gene nm23 in Human Malignant Melanoma

Liu Danya1, Su Baoshan2, Xu Hanqing1   

  1. Departmant of Dermatology, Second Affliated Hospital of Xi'an Medical University, Xi'an 710004
  • Received:1995-06-19 Revised:1995-09-25 Online:1996-02-15 Published:1996-02-15

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摘要： 为了研究nm23/二磷酸核苷激酶(NDPK)表达与人恶性黑素瘤(恶黑)转移潜力的关系,我们用免疫组化技术研究了恶黑组织中nm23基因的表达,以及表达程度与组织病理、细胞DNA含量、增殖指数和临床预后的相关性。结果发现nm23/NDPK在转移性恶黑及原发性恶黑伴淋巴结转移时表达减低。其表达程度与DNA含量及增殖指数呈负相关,而与临床分期无关。另外,nm23/NDPK表达程度高者生存时间较表达低者长。结果提示:nm23基因表达对恶黑的转移具有负调控作用,其表达低者意味着肿瘤组织具有高转移潜能。nm23/NDPK的作用机理可能是通过影响细胞微管的聚合而发挥作用。

关键词: 恶性黑素瘤, nm23基因

Abstract: The present study was conducted to clarify the association of nm23 expression with metastatic potential in human malignant melanoma(MM).The expression of am23 gene was studied using immunohistochemical method in human malignant melanoma,and association of extent of expression of nm23/NDPK with histopathological classification,DNA contents and prognosis was analyzed.The expression of nm23/NDPK in patients with metastatic malignant melanoma and primary malignant melanoma with lymph node metastasis was significantly reduced than in patients without metastasis. The intensity of nm23/NDPK was negatively correlated with DNA contents and proliferation index,but not correlated with histopathological classification of tumor.Additionally patients with increased expression of nm23/NDPK may have longer survival time than patients with reduced expression.Our results implicated that the expression of nm23 gene may suppress the metastasis of malignant melanoma.The tumor With low nm23/NDPK level indicates a high metastatic potential.The mechanism of action of nm23 may modulate the polymerization of cellular microtuble in tumor cells.

Key words: Malignent melanoma, nm23 gene