中华皮肤科杂志 ›› 1995, Vol. 28 ›› Issue (1): 11-13.

• 论著 • 上一篇    下一篇

皮肤鳞状上皮肿瘤中myc及ras癌基因产物P62及P21的检测

孙建方, 刘季和, 桑红桂, 李阿梅, 高新元   

  1. 中国医学科学院、南京中国协和医科大学皮肤病研究所 南京 210042
  • 收稿日期:1994-03-12 修回日期:1994-06-14 出版日期:1995-02-15 发布日期:1995-02-15

Examination of Myc and Ras Oncogene Products P62 and P21 on Specimens of Squamous Epithelial Tumors of the Skin

Sun Jianfang, Liu Jihe, Sang Honggui   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042
  • Received:1994-03-12 Revised:1994-06-14 Online:1995-02-15 Published:1995-02-15

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摘要： 用抗myc及ras癌基因产物的单克隆抗体P62及P21,对27份皮肤鳞状上皮肿瘤(SETS)标本进行了免疫组化检测.结果:62.9%的标本表达P62蛋白,66.7%的标本表达P21蛋白,13份标本同时表达P62及P21两种蛋白;此外,结果还显示P62蛋白多见于分化较差的SETS,而P21则在相对分化较好的SETS中较多.我们认为myc及ras癌基因在SETS的发病中可能有不同的意义,二种癌基因的协同作用可能与SETS的持续生长有关.

关键词: 癌基因, 鳞状上皮肿瘤, 皮肤肿瘤

Abstract: With anti-myc and ras oncogene product monoclonal antibodies P62 and P21,27 cases of squamous epithelial tumors of the skin (SETS) specimens were examined.The results showed that 62.9%(17/27) and 66.7%(18/27) of the specimens expressed P62 and P21 proteins respectively.Thirteen specimens expressed P62 and P21 proteins simultaneously.The results also showed that P62 was mainly seen in the poorly differentiated squamous cell carcinoma specimens,while P21 was mainly in the relatively well-differentiated specimens.The authors consider that myc and ras oncogenes might have different effects on the develpment of the SETS,and their synergy might be associated with the persistant growth of SETS.

Key words: Oncogene Squamous epithelial tumors, Skin neoplasms