中华皮肤科杂志 ›› 1994, Vol. 27 ›› Issue (5): 288-290,330.

• 论著 • 上一篇    下一篇

麻风患者治疗前后血清麻风杆菌特异性抗原和抗体的变化

曹元华1, 和泉真藏2, 川津邦雄2, 吴勤学1   

  1. 1. 中国医学科学院、中国协和医科大学皮肤病研究所, 南京210042;
    2. 日本厚生省国立多摩研究所
  • 收稿日期:1993-09-27 修回日期:1994-03-27 出版日期:1994-10-15 发布日期:1994-10-15

Detection of PGL-I Antigen and Antibody Before and After Treatment in Leprosy Patients

CAO Yuan-Hua1, Izumi S2   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042
  • Received:1993-09-27 Revised:1994-03-27 Online:1994-10-15 Published:1994-10-15

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摘要： 用免疫斑点试验改良法(M-Dot-ELISA)和酶联免疫吸附试验(ELISA)对10例多菌型麻风患者治疗前后的99份血清进行了PGL-I抗原和抗体检测。结果表明治疗前后及治疗中各段时间的抗原下降速度远快于抗体,二者之间有非常显着性差异(U=9.05,>2.58,P<0,01).抗原量的下降以治疗后第1个月最快(79.14%),治疗第3个月时已下降99%以上,这提示抗原的检测可用于监测多菌型麻风的早期疗效,在发现耐药和抗麻风新药筛选方面亦有应用价值。

关键词: 麻风, 药物疗法, 抗原

Abstract: We report the results of detecting anti-PGL-I antigen and antibody in sera from lepromatous leprosy patients before and after MDT with M-DotELISA and ELISA. The results indicated that the speed of antigen reducing in the sera of patients was much faster that that of antibody reducing after chemotherpy, the difference is very significant(U=9.05, >2.58, P<0.01). The decreasing of PGL-I antigen was fastest (79.14%)at the first month and was 99% decreasing at the third months. It suggests that the detection of PGL-I antigen might be used for monitoring the early therapeutic effect in mutibacillary leprosy, finding out of drug-resistant M. leprae strains, and screening of new drugs for the treatment of leprosy.

Key words: Leprosy, Drug therapy, Antigen, detection