中华皮肤科杂志 ›› 1994, Vol. 27 ›› Issue (3): 136-138,188.

• 论著 • 上一篇    下一篇

白念珠菌芽管特异性抗原的研究

王鲁, 叶庆佾, 唐书谦   

  1. 第三军医大学西南医院皮肤科 重庆 630038
  • 收稿日期:1993-06-18 修回日期:1993-12-14 出版日期:1994-06-15 发布日期:1994-06-15

Study of Germ Tube-Specific Antigens of Candida Albicans

WANG Lu, YE Qing-Yi, TANG Shu-Qian   

  1. Department of Dermatology, South-West Hospital, The Third Military Medical College, Chongqing 630038
  • Received:1993-06-18 Revised:1993-12-14 Online:1994-06-15 Published:1994-06-15

摘要: 运用ⅡF、SDS-PAGE和免疫印迹技术,证实8株临床分离的白念珠菌芽管表面存在芽管特异性抗原.白念珠菌菌丝相胞壁提取物中含有比孢子相更多的、不同的蛋白成份;发现白念珠菌菌丝相胞壁提取物中有一分子量大约为39000蛋白抗原成份很可能是白念珠菌芽管特异性抗原;认为白念珠菌孢子相和其它念珠菌孢子相胞壁中有以隐蔽状态存在的芽管抗原成份.

关键词: 白念珠菌, 抗原,芽管特异性

Abstract: ByⅡF,SDS-PAGE and Western blot technique,it was confirmed that there were germ tube-specific antigens on the surfaces of germ tubes of C.albicans which were isolated from clinical specimens.The mycelialphase extract of C.albicans contained a more varied array of proteins than those of the yeast-phase extract.We found a protein component (molecular weight,39 000)in cell wall extracts of mycelial-phase,which may be a germ tube-specific antigen of C.albicans.It is our opinion that there may be germ tube antigens in a cryptic state not only in the cell walls of yeast-phase of C.albicans but in other candida species.

Key words: C.albicans, Antigen,germ tubespecific