中华皮肤科杂志 ›› 1994, Vol. 27 ›› Issue (3): 134-135,188.

• 论著 • 上一篇    下一篇

六种抗菌药物体外对解脲支原体与人型支原体的抗菌作用

吴移谋, 余敏君, 刘腾飞, 占利生, 尹卫国   

  1. 衡阳医学院微生物学教研室 湖南 421001
  • 收稿日期:1993-08-16 修回日期:1993-11-23 出版日期:1994-06-15 发布日期:1994-06-15

In Vitro Antibacterial Activities of 6 Antimicrobial Agents Against Ureaplasma Urealyticum and Mycoplasma Hominis

WU Yi-Mou, YU Min-Jun, LIU Teng-Fei   

  1. Department of Microbiology, Hengyang Medical College, Hu'nan 421001
  • Received:1993-08-16 Revised:1993-11-23 Online:1994-06-15 Published:1994-06-15

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摘要： 采用琼脂对倍稀释方法,测定了6种国产抗菌药物对30株解脲支原体(Uu)、30株人型支原体(Mh)体外抗菌作用效果.结果显示:乙酰螺旋霉素、氟哌酸和强力霉素有较强的抗Uu与Mh作用.乙酰螺旋霉素抗 Uu的 MIC50与 MIC90为0.25mg/L与1mg/L,抗Mh为0.5mg/L与1mg/L.氟哌酸抗 Uu与Mh作用相同,MIC50与MIC90为0.5mg/L与1mg/L.强力霉素抗Uu的MIC50与MIC90为0.5mg/L与1mg/L,抗Mh为0.25mg/L与2mg/L.Mh对红霉素有高度抵抗作用,MIC50与MIC90为64mg/L与128mg/L.6株 Uu、4株Mh对四环素高度耐药,MIC50与 MIC90分别为64mg/L与128mg/L和16mg/L与32mg/L,但对其它抗菌药物敏感.小檗硷抗Uu与Mh作用相同,MIC50与MIC90为4mg/L与8mg/L,对耐四环素的Uu与Mh也有相同的抗菌作用.

关键词: 解脲支原体, 人型支原体, 抗生素类

Abstract: In this report,in vitro antibacterial activities of 6 antimicrobial agents against 30 strains of Urea plasma urealyticum (Un),30 strains of Mycoplasma hominis (Mh)were determined using agar dilution method.The results indicated that acetylspiramycin,norfloxacin and doxycycline are highly active against Uu and Mh.Acetylspiramycin is active against Uu,MIC50 0.25mg/L,and MIC90 1mg/L,against Mh,MIC50 0.5mg/L and MIC90 1mg/L.Norfloxacin is equally active against Un and Mh,MICS,0.5mg/L and MIC50 1mg/L.Doxycycline is active against Uu and Mh,for Un MIC50 is 0.5mg/L and MIC90 1mg/L,and for Mh MIC50 is 0.25 and MIC90 2mg/L.Mh is resistant to erythromycin (MIC50 60mg/L and MIC90 128mg/L).Six strains of Un and 4 strains of Mh are highly resistant to tetracycline (MIC50 64 to 128mg/L and MIC90 16 to 32mg/L)and yet still sensitive to the other antimicrobial agents.Berberine is equally active against Uu and Mh (MIC50 4mg/L and MIC90,8mg/L) and is effective for the tetracycline resistant strains of Uu and Mh.

Key words: Ureaplasma urealyticum, Mycoplasma hominis, Antibiotics