中华皮肤科杂志 ›› 1994, Vol. 27 ›› Issue (2): 72-75,126,127.

• 论著 • 上一篇    下一篇

34例皮肤混合瘤的病理和免疫组织化学研究

孔令城1, 朱雄增2, 刘尚廉2, 赵保华1   

  1. 1. 上海市第一人民医院病理科, 200085;
    2. 上海医科大学肿瘤医院病理科免疫组化室
  • 收稿日期:1993-02-13 修回日期:1993-05-08 出版日期:1994-04-15 发布日期:1994-04-15

Mixed Tumors of the Skin: A Clinicopathological and Immunohistochemical Study of 34 Cases

KONG Jin-Cheng1, ZHU Xiong-Zeng2, LIU Shang-Lian2   

  1. Department of Pathology, Shanghai First People's Hospital, Shanghai 200085
  • Received:1993-02-13 Revised:1993-05-08 Online:1994-04-15 Published:1994-04-15

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摘要： 34例皮肤混合瘤中15例用11种抗体作免疫组化研究,以便建立肿瘤的分类及阐明组织起源。结果如下:①皮肤混合瘤基本可分为大汗腺型和小汗腺型,大汗腺型比小汗腺型远为常见。②肿志的上皮成分可分为管腺性、实巢性及间质性上皮。管腺内层细胞有明显上皮特征,其角蛋白、癌胚抗原(CEA)及上皮细胞膜抗原(EMA)均阳性,而外层细胞对结蛋白(Desmin,Des)、肌动蛋白(Actin)、CEA及EMA呈阴性,对波形蛋白(Vimentin,Vim).S100蛋白、细胞角蛋白(Cytokeratin,CK,11例)、神经原特异性烯醇化酶(NSE,8例)及胶质纤维酸性蛋白(GFAP,6例)均呈阳性。间质细胞与实巢上皮的免疫表达相似于管腺外层细胞,提示肿瘤的问质成分既可来自管腺的外层细胞,也或来自多潜能干细胞,但不能证实为唯一肌上皮起源。

关键词: 汗腺肿瘤, 病理学,临床, 免疫组织化学

Abstract: The clinicopathological features of 34 cases of cutaneous mixed tumor are reported.The specimens of 15 cases were studied immunohistochemically with 11 kinds of antibodies in order to establish their classification and to elucidate their histogenesis.The results were as follows: (1) Mixed tumors of the skin were basically apocrine or eccrine in type,apocrine type of mixed tumor was much more common than the eccrine one.(2)The epithelial elements of these tumors could be classified as tubuloglandular,solid nests and stromal cells.The inner cell layers of tubuloglandular components had distinct epithelial features,expressing keratin,carcinoembryonic antigen (CEA) and epithelial membrane antigen (EMA).The outer cell layers had negative results for actin, desmin, CEA, and EMA, and had positive results for vimentin, S100 protein, cytokeratin (11 cases), neuron-specific enolase (8 cases), and glial fibrillary acidic protein (6 cases).The immunophenotypes of stromal cells and solid nests were similar to those of the outer cell layers.These date suggest that the stromal components may derive either from the outer cells of the tubuloglandular elements or pluripotent stem cells, but can not confirm their exclusive myoepithelial origin.

Key words: Sweat gland neoplasms, Pathology, clinical, Immunohistochemistry