中华皮肤科杂志 ›› 1994, Vol. 27 ›› Issue (2): 70-71,126.

• 论著 • 上一篇    下一篇

HMB-45抗原在毛囊黑素细胞中的表达

程浩1, Thiele B2, Wollf H H2   

  1. 1. 浙江医科大学附属第二医院皮肤科, 杭州, 310009;
    2. 德国吕贝克医科大学皮肤病院
  • 收稿日期:1993-04-26 修回日期:1993-08-17 出版日期:1994-04-15 发布日期:1994-04-15

Expression of HMB-45 Antigen in melanocytes of Hair Follicles

CHENG Hao1, THIELE B2, WOLLF H H2   

  1. Department of Dermatology, The Second Affiliated Hospital, Zhejiang Medical University, Hangzhou 310009
  • Received:1993-04-26 Revised:1993-08-17 Online:1994-04-15 Published:1994-04-15

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摘要： 用单克隆抗体HMB-45,以APAAP法对20份头皮活检标本的98个毛囊组织进行染色。其中20个毛囊为生长早期,63个为成熟生长期,7个为退行期和8个是休止期。结果,52个成熟生长期及20个生长早期毛囊的黑素细胞与单克隆抗体HMB-45显着结合。所有退行期、休止期及工11个成熟生长期毛囊未被染色。结果提示;HMB-45在毛囊中的表达随毛发生过周期而变化,且与黑素细胞功能活性状态有关。

关键词: 毛囊, 黑素细胞, 抗体, 单克隆

Abstract: In the present study, biopsy specimens of the scalp of 20 patients were stained with antibody directed against HMB-45.20 out of 98 hair bulbs were in the early anagen phase, 63 were mature anagen, 7 were catagen and 8 showed a typical telogen feature.In 52 out of 63 mature anagen and all 20 early anagen hair bulbs, the melanocytes were strongly stained with HMB-45.In contrast, melanocytes in 11 mature anagen bulbs as well as in catagen or telogen phase were not stained.Our findings suggest that the expression of HMB-45 antigen in melanocytes of hair bulbs is strongly related to the cell cycle of hair,i.e.HMB-45 antigen only binds to the active or proliferating melanocytes in early and mature anagen hair follicles,but not to the inactive or dedifferentiated melanocytes in catagen of telogen hair follicles.

Key words: Melanocytes, Antibodies, monoclonal, Hair follicles