中华皮肤科杂志 ›› 1994, Vol. 27 ›› Issue (1): 6-9,61.

• 论著 • 上一篇    下一篇

培养黑素细胞对白癜风患者淋巴细胞增殖反应的研究

赵辨, 陈希平, 黄曼倩   

  1. 南京医科大学第一附属医院皮肤免疫研究室, 210029
  • 收稿日期:1993-01-09 修回日期:1993-05-12 出版日期:1994-02-15 发布日期:1994-02-15
  • 基金资助:
    国家自然科学基金资助项目

In Vitro Proliferative Responses of Pymphocytes Obtained from Vitiligo patients to Cultured Normal Melanocytes

ZHAO Bian, CHEN Xi-Ping, HUANG Man-Qian   

  1. The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029
  • Received:1993-01-09 Revised:1993-05-12 Online:1994-02-15 Published:1994-02-15

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摘要： 我们以培养的正常人黑素细胞为特异性抗原研究了白癜风患者淋巴细胞的增殖反应。结果26例白癜风患者的特异性淋巴细胞转化试验,3H TdR掺入平均cpm值为203.48±28.94,22例健康对照组3H TdR掺入平均cpm值为99.03±12.15,显示患者淋巴细胞增殖反应明显高于正常者。经统计学分析两者差异有显着意义(P=0.0031).而与性别、病程无相关关系。提示白癫风的发病与细胞免疫异常有关。

关键词: 白癜风, 黑素细胞, 淋巴细胞转化

Abstract: The proliferative responses of lymphocytes of vitiligo patients to cultured normal human melanocytes were studied. Lymphocyte transformation test with cultured normal melanocytes as specific antigen was performed in 26 vitiligo patients and 22 healthy individuals as control. It was found that the incorporation of 3HTdR in the vitiligo patients was 230.48±28.94 cpm, while 99.03±12.15 cpm in the controls. The results indicated that the patients with vitiligo had a signihcantly increased proliferative responses of lymphocytes to normal melanocytes in comparisons with the controls. The proliferative responses of lymphocytes showed no correlation with the sex or disease duration in the patients. The results suggest that aberrations in cell-mediated immunity may play a role in the pathogenesis of vitiligo.

Key words: Vitiligo, Melanocyte, Lymphocyte transformation