中华皮肤科杂志 ›› 1994, Vol. 27 ›› Issue (1): 19-21,62.

• 论著 • 上一篇    下一篇

即时型PUVA对郎格罕细胞和接触过敏的影响

郭在培1, 冈本祜之2, 段野贵一郎2, 今村贞夫2   

  1. 1. 华西医科大学附属第一医院皮肤科, 成都610041;
    2. 日本京都大学皮肤科
  • 收稿日期:1992-12-04 修回日期:1993-06-20 出版日期:1994-02-15 发布日期:1994-02-15

Effects of Non-interval PUVA Treatment on Langerhans Cells and Contact Hypersensitivity

GUO Zai-Pei1, Hiroyuki Okamoto2, Kiichiro Danno2, Sadao Imamera2   

  1. 1. Department of Dermatology, The First Hospital, West China University of Medical Sciences;
    2. Department of Dermatology, Faculty of Medicine, Kyoto University, Japan
  • Received:1992-12-04 Revised:1993-06-20 Online:1994-02-15 Published:1994-02-15

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摘要： 在实验动物中研究了即时型光化学疗法对表皮郎格单细胞数量和形态的影响及对接触过敏反应的抑制,并与常规使用的光化学疗法进行了对比,结果表明二种方法间无差异,3J/cm2的即时型光化学疗法无红斑反应并能引起郎格罕细胞数量和形态的变化,并且通过诱导抑制性淋巴细胞抑制接触过敏反应。还探讨了有关致癌的可能性。

关键词: PUVA疗法, 皮炎,接触, 郎格罕细胞

Abstract: Although application of topical psoralen followed immediately by ultraviolet-A irradiation (non-interval PUVA) was reported to be effective in the treatment of psoriasis, its precise mechanisms of action have not yet been explored. Since regular topical PUVA therapy, consisting of topical application of psoralen followed by UVA exposure 1-2 h later, can change the number and morphology of Langerhans cell (LC) and inhibit contact hypersensitivity (CHS). We investigated Whether these same effects may be induced by non-interval PUVA in experimental animals. Our resulos showed that no differences exist between these two types of PUVA treatment. Non-interval PUVA treatment of 3J/cm2 produced no erythematous reactions and resulted in changes in the number and morphology of LC. The non-interval regimen also inhibited CHS to DNFB applied to the treated skin by inducing the suppressor lymphocytes. We also discussed the carcinogenic potential by non-interval PUVA.

Key words: PUVA therapy, Langerhans cell, Dermatitis, contact