中华皮肤科杂志 ›› 1994, Vol. 27 ›› Issue (1): 13-15,61,62.

• 论著 • 上一篇    下一篇

牛脾转移因子及白三烯C4与异位性皮炎

王玉英1, 李世荫1, 王晶1, 李巍2, 方一夫2, 刘景生2   

  1. 1. 北京医科大学第三临床医学院皮肤科, 100083;
    2. 中国医学科学院基础医学研究所药理教研室
  • 收稿日期:1992-08-04 修回日期:1993-06-04 出版日期:1994-02-15 发布日期:1994-02-15

Study of OBS-TF, LTC4 and Atopic Dermatitis

WANG Yu-Ying1, LI Shi-Yin1, WANG Jing1   

  1. Department of Dermatology No. 3 School of Clinical Medicine, Beijing Medical University, Beijing 100083
  • Received:1992-08-04 Revised:1993-06-04 Online:1994-02-15 Published:1994-02-15

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摘要： 用牛脾转移因子口服液(OBS-TF)治疗异位性皮炎(AD)28例,井采用3H放兔法测定了OBS-TF治疗前后AD患者及正常人血浆及外周血白细胞(PBL)中白三烯C4(LTC4)含量。AD血浆及PBL中LTC4含量治疗前均明显高于正常人,治疗后则无显着差异,AD的严重程度与LTC4水平相乎行,提示LTC4可能作为强效炎症介质之一介入了AD的发病过程, OBS-TF则可能作为LTC4的抑制剂对AD发挥了治疗作用。

关键词: 皮炎,特应性, 白细胞三烯C4, 转移因于

Abstract: Using 3H radioimmunoassy, the levels of leukotriene C4 (LTC4) were determined in 25 atopic dermatitis (AD) patients before and after the treatment of oral bovine spleen transfer factor (OBS-TF) and 33 normal controls. The results revealed that the seventy of AD presented a positive correlation with the level of LAC4, and the levels of LTC4 in both plasma and peripheral blood leukocytes (PBL)in AD were markedly higher than those of normal donors (P<0.001). The authors found that the OBS-TF could significantly reduce the levels of LTC4 in both plasma and PBL, and significantly improve the symptoms and signs of AD. The results of our study indicated that LTC4 may be involved in the pathogenetic process of AD as one of the strong inflammatory mediators, and OBS-TF may play an important role as an inhibitor of LTC4 in AD.

Key words: Dermatitis,atopic, Leukotriene C4, Transfer factor