中华皮肤科杂志 ›› 1993, Vol. 26 ›› Issue (4): 210-212.

• 论著 • 上一篇    下一篇

急性荨麻疹和慢性荨麻疹患者血浆成分吸附组胺能力的测定

施伟民1, 张传钧2   

  1. 1. 上海铁道医学院附属甘泉医院皮肤科, 200061;
    2. 上海第二医科大学附属瑞金医院皮肤科
  • 收稿日期:1992-06-16 修回日期:1993-01-14 出版日期:1993-08-15 发布日期:1993-08-15

The assessment of histaminopexic ability of some plasma constituents in patients with acute and chronic urticaria

SHI Wei-Ming1, ZHANG Chuan-Jun2   

  1. Dermatology Department, Gan Quan Hospital, Shanghai Railway Medical College, 200061
  • Received:1992-06-16 Revised:1993-01-14 Online:1993-08-15 Published:1993-08-15

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摘要： 采用高效液相层析技术以快速、简便地枪测人体血浆组胺(HA)含量及血浆成份吸附HA的能力.结果显示正常人血浆HA含盈为0.07-0.18ng/ml(n=22).单位量丙种球蛋白HA吸附率显著大于白蛋白,单位量血浆中白蛋白吸附HA总量显著大于丙种球蛋白的吸附摄.正常人每毫升血桨HA吸附率约为93.68±5.43%.急性尊麻疹及慢性尊麻疹发作期血浆HA水平明显升高(P<0.01),血浆HA吸附率明显下降(P<0.01)0急性尊麻疹皮损消退时,血浆HA水平略高于正常,血浆HA吸附率恢复正常,而慢性尊麻疹皮损消退后血浆HA水平及血浆HA吸附串皆恢复正常.

关键词: 荨麻疹, 组胺, 组胺吸附率

Abstract: This paper reports the use of high perfarmance liquid chromatography (HPLC) technique in the detection of histamine content (HC) and histaminopexet raft (HR) of some plasma constituents in patients with acute urticaria (AU) and chronic urticaria (CU). The result showed that the HC of normal controls was 0.70±0.18ng/ml (n=22), the HR of γ-globulin per unit weight significantly higher than that of albumin. The HR of albnmin in plasma of unit volume was significantly higher than that of γ-globulin. The HR of plasma per ml in normal controls was about 93.68±5.43%. We found that the plasma HC in patients with AU and CU (in onset stage) was significantly higher (P<0.01) and the HR significantly lower (P<0.01) than those of normal controls. When the skin eruption of AU disappeared, the HC was stillalightly higher than that of normal, but the HR returned to normal. Both the plasma HC and HR in CU became normal after disappearance of the eruption.

Key words: Urticaria, Histamine, Histaminpexic, rate