中华皮肤科杂志 ›› 1993, Vol. 26 ›› Issue (3): 156-158.

• 论著 • 上一篇    下一篇

异位性皮炎皮损处郎格罕细胞的抗CD23/FcεRⅡ反应性

王秉鹤1, Rieger A2, Wolff K2, Stingl G2   

  1. 1. 南京医学院第一附属医院皮肤科, 南京, 210029;
    2. 奥地利维也纳大学皮肤免疫生物学研究室
  • 收稿日期:1992-05-12 修回日期:1992-10-19 出版日期:1993-06-15 发布日期:1993-06-15

Anti-FcεRⅡ/CD23 reactivity on Langerhans cells in atopic dermatitis skin lesions

WANG Bing-He1, Rieger A2   

  1. First Affiliated Hospital, Nanjing Medical College, Nanjing, 210029
  • Received:1992-05-12 Revised:1992-10-19 Online:1993-06-15 Published:1993-06-15

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摘要： 郎格罕细胞(LC)携带IgE是异位性皮炎(AD)的特征.为探索IgE如何结合至LC,检查了AD皮肤中抗CD23/FcεRⅡ反应性.26例AD皮损中18例检出抗CD23单克隆抗体MHM6反应性细胞.双重标记表明部分MHM6+细胞是CDla+LC.酸处理导致MHM6及抗IgE反应性丧失,但LC的IgE结合能力并不受影响,表明CD23/FcεRⅡ虽能从AD皮肤LC上检出,并不为LC结合馆E所必需.推测IgE通过FcεRⅡ以外的受体而结合至LC.

关键词: 异位性皮炎, 郎格罕细胞, IgE, Fc受体, CD23

Abstract: Occurrence of IgE molecules qn Langerhans cells (LC) in lesional sites of atopic dermantis (AD) is a feature of this disease. The events of IgL binding on LC is unknown. In order to address this issue, we examined the presence of the low affinity IgL-Fc receptor (FcεRⅡ/CD23). In 18/26 cases, we detected cells which reacted with one particular antiCD23 mAb MHM6 in Iesional skin. Double immunoiabelling experiments revealed that a portion of MHM6+ cells was CD1a+LC. Preexposurce of AD sections to glycine-HCl (pH2.5) led to a Loss of MHM6-and anti-IgE-reactive cellular sites. In contrast, the IgE-binding capacity of LC was not affected by acid Ereatment. These observations suggest that FcεRⅡ/CD23, although detected nn LC in AD skin, is nut required for cellular IgE-binding and lead to the hypoEhesis that IgE can bind to LC via a receptor other than FcεRⅡ.

Key words: Atopic dermatitis, Langerhans cell, IgE receptor CD23