中华皮肤科杂志 ›› 1992, Vol. 25 ›› Issue (5): 300-303.

• 论著 • 上一篇    下一篇

ELISA和明胶微粒凝集试验检测麻风病人及接触者血清抗体

孙显光1, 褚桂芝1, 刘国才2, 叶福昌2   

  1. 1. 贵州省皮肤病防治研究所, 贵阳, 550001;
    2. 指导者
  • 收稿日期:1991-04-02 修回日期:1991-12-30 出版日期:1992-10-15 发布日期:1992-10-15
  • 基金资助:
    贵州省科学技术基金资助课题

Analysis of Serum Antibodies in Patients with Leprosy and Leprosy Contacts by ELISA and MLPA

SUN Xian-Guang1, CHU Gui-Zhi1   

  1. Guizhou Proairicial Institute of Dermatology of Preacnriore and Treatment, Guiyang 550001
  • Received:1991-04-02 Revised:1991-12-30 Online:1992-10-15 Published:1992-10-15

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摘要： 用半合成酚糖脂抗原(NT-O-BSA)间接酶联免疫吸附试yan(ELISA)和半合成爵糖脂抗原(NT-P-BSA)致敏明胶微粒凝集试验(MLPA).检测贵州省12县麻风病人密切接触者血清抗体1715例,现症麻风病人137例:结果:接触者阳性率ELISA和MLPA分别为17.84%和13.94%(R=4.8514,P=0.0004);麻风病人阳性率分别为91.97和89.78% (X2=0.0083,P>0.5,在活动性肺结核病人及正常人的结果相同和相近.上述结果表明ELISA和MLIPA具有较高的敏感性和较好的特异性,且接触者血清抗体阳性率与各地麻风病患病率和发病率呈显著正相关.提示接触者抗体测定除可作为检测麻风菌感染外也许还可预测麻风病的流行.

关键词: 麻风, 抗体

Abstract: In this paper,the,serum PGL-1 antibodies of 1715 cases of close contacts of leprosy and 137 cases of leprosy were determined by NT-O-BSA-ELISA and MLPA in 12 counties of Guizhou Province.

Key words: Leprosy Antibodies