甲氟哌酸与氟嗦酸、利福平在正常小鼠体内抗麻风菌的活性比较

中华皮肤科杂志 ›› 1992, Vol. 25 ›› Issue (5): 297-299.

甲氟哌酸与氟嗦酸、利福平在正常小鼠体内抗麻风菌的活性比较

沈建平¹, 李文忠¹, 朱崇泉², 王荷英¹, 喻林冲¹, 施美琴¹, 叶干运¹

1. 中国医学科学院皮肤病研究所, 南京, 210042;
2. 南京药物研究所

收稿日期:1991-09-19 修回日期:1992-01-03 出版日期:1992-10-15 发布日期:1992-10-15

Comparison of Peflosacia, Oflosacin and Rifanmpin Against M.leprae in Normal mice

SHEN Jian-Ping¹, LI Wen-Zhong¹

Institute of Dermatadogy, Chinese Academy of Medical Sciences, Nanjing 210042

Received:1991-09-19 Revised:1992-01-03 Online:1992-10-15 Published:1992-10-15

摘要/Abstract

摘要： 报告国产甲氟哌酸在免疫正常小鼠中的抗麻风杆菌活性,并与进口氮嗦酸、利福平的抗菌活性比较实验采用动力法,结果示国产甲氛哌酸150mg/kg,每周管饲5次,给药80天,可使麻风菌生长推迟138天,推算杀菌率为97.08%.氛嗦酸在给药剂量及方法与国产甲氟呢酸相同时.结果与利福平10mg/kg,每周管饲1次时的相同.两治疗组小鼠足垫内均未见麻风菌生长.甲氟呢酸和氛嗓酸在以150mg/kg,每周管饲1次时,两药仅显示类似程度的抑菌活性.

关键词: 麻风抑制剂, 麻风分枝杆菌

Abstract: The paper reports the activity of homemade Pefloxacin (PFLO) against M.leprae in the normal mice,and the result are comparied with those of Ofloxacin (OFLO,made in Japan) and Rifampin (RFP).

Key words: Leprostatic agents, Mycohac-Cerium leprae

沈建平, 李文忠, 朱崇泉, 王荷英, 喻林冲, 施美琴, 叶干运. 甲氟哌酸与氟嗦酸、利福平在正常小鼠体内抗麻风菌的活性比较[J]. 中华皮肤科杂志, 1992, 25(5): 297-299.

SHEN Jian-Ping, LI Wen-Zhong. Comparison of Peflosacia, Oflosacin and Rifanmpin Against M.leprae in Normal mice[J]. Chinese Journal of Dermatology, 1992, 25(5): 297-299.