中华皮肤科杂志 ›› 1992, Vol. 25 ›› Issue (4): 224-227.

• 论著 • 上一篇    下一篇

季节性面部接触性皮炎致病因素及其发病机理的初步探讨

刘彦群, 赵辨   

  1. 南京医学院第一附属医院皮肤科
  • 收稿日期:1991-05-16 修回日期:1991-10-04 出版日期:1992-08-15 发布日期:1992-08-15

Study on etiology and pathogenesis of seasanal facial contact dermatitis

LIU Yan-Qun   

  1. The First Affiliated Hospital, Nanjing Medical College, Nanjing, 210029
  • Received:1991-05-16 Revised:1991-10-04 Online:1992-08-15 Published:1992-08-15

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摘要： 报告51例季节性,87例非季节性面部接触性皮炎致病因素的调查,并选择20例健康者作为对照.结果,季节组欧抗斑试阳性率明显低于非季节组,且与健康组无显著差异.季节组花粉皮肤划痕试验、血清总rgE及特异性rgE的阳性率均明显高于非季节组及健康组,且非季节组与健康组均无显著差异.季节组皮肤划痕试验与特异性IgE,特异性IgE与总IgE及总IgE与皮肤划痕试验皆有明显相关,符合率分别为75.6%,70.7%,75.6%a结果表明花粉是季节性面部接触性皮炎的重要致病因素,其发病机理可能与IgE介导的迟缓相皮肤反应有关.

关键词: 皮炎,接触性, 花粉抗原, 免疫球蛋白类, 迟缓相反应

Abstract: This paper reports the etiology investigation of 51 cases of seasonal facial contact dermatitis (SG) and 87 cases of nonseasonaf facial contact dermatitis (NSG) along with 20 healthy control (HCG). The positive rate of European Standard Allergens patch test in SG was found to be significantly lower than that in NSG (P<0.005), but no significant difference was observed between SG and HCG (P>0.25). The positive rate of pollen allergen skin scratch test (SST) in SG was significantly higher than that in NSG (P<0.005) and in HCG (P<0.005). The positive rates of total IgE and speciFc IgE; were higher in SG than those in NSG (P<0.01) and HCG (P<0.01) respectively, while no significant difference was found between NSG and HCG.The positive correlation were found in SG between specific IgE and SST results (P<0.005, agreement 75.6%) and between SST results and total IgE (P<0.005, agreement 75.6%) and between total IgE and specific IgE (P<0.01, agreement 70.7%). Our results indicate that the pollen is an important etiological factor of seasonal Facial contact dermatitis. The IgE mediated late phase cutaneous reaction may be involved in the pathogenesis of this disease.

Key words: Dermatitis, contact, Pollen allerzens Immunoglobulins, Late phase reaction