中华皮肤科杂志 ›› 1992, Vol. 25 ›› Issue (4): 222-223.

• 论著 • 上一篇    下一篇

无色素性恶性黑素瘤免疫组化诊断研究

高天文, 刘荣卿, 叶庆佾   

  1. 第三军医大学第一附属医院皮肤科, 重庆, 6300038
  • 收稿日期:1991-04-22 修回日期:1991-08-10 出版日期:1992-08-15 发布日期:1992-08-15
  • 基金资助:
    国家自然科学基金资助项目

Study on immunohistochemical differential diagnosis for amelanotic malignant melanoma

GAO Tian-Weng   

  1. Snuth-western Hospital, The Third Military Medical College, Chongqing, 630038
  • Received:1991-04-22 Revised:1991-08-10 Online:1992-08-15 Published:1992-08-15

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摘要： 应用抗S100蛋白、波形纤维蛋白、神经特异性烯醇化酶、角蛋白、细胞角蛋白及癌胚抗原抗体,以ABC法对46例临床病例诊断或疑诊为无色素性恶性黑素瘤(AMM)的组织进行染色,并以22例诊断恶性黑素瘤(MM)的含色素标本对照.结果:33例诊断及13例疑诊MM的无色素组织中,共9例不符合原诊断.22例含色素组织中1例不符合原诊断.结果提示:抗S100蛋白抗体、波形纤维蛋白抗体联合应用,对AMM的诊断具有重要鉴别意义.

关键词: 黑素瘤, 免疫组织化学

Abstract: Forty-six patients clinically diagnosed as arnelanoiic malignant or elanotnas (AMM) or suspected AMM were analyzed with anti-S100 protein, vixnentin, NSE, keratin, cytokeratin and CEA antilsodies by means of ABC method. Twenty-two patients diagnosed as pigmented malignant snelanamas (PAZM) were stained with the same methods as control.The results showed that 9 cases out of 33 patents clinically diagnosed as AMM and 13 suspected AMM did not accord with AMM in diagnosis, and one case out of 22 suspected PMM did not accord with PMM. The results suggest that using both anti-S100 protein and vimentin antibodies has an important value for the differerxtial diagnosis of AMM.

Key words: Melanoma, Isnmunohistochemistry