中华皮肤科杂志 ›› 1992, Vol. 25 ›› Issue (1): 6-7.

• 论著 • 上一篇    下一篇

BXSB小鼠血清抗核抗体与肾小球免疫球蛋白沉着情况的检测与分析

邓鸿业, 张新, 常江, 邹万忠   

  1. 北京医科大学免疫学教究室, 100083
  • 收稿日期:1990-09-01 修回日期:1991-01-02 出版日期:1992-02-15 发布日期:1992-02-15
  • 基金资助:
    国家自然科学基金资助项目

Assays and Analysis of Serum Antinuclear Antibody and Glomerular lg Deposit In BXSB Mice

DENG Nong-Ye, CHANG Xin   

  1. Beijing Medical University, 100083
  • Received:1990-09-01 Revised:1991-01-02 Online:1992-02-15 Published:1992-02-15

摘要: 对不同月龄和性别的BXSB小鼠(自发SLE的小鼠模型之一)的血清抗核抗体(ANA)水平及肾小球中免疫球蛋白(lg)沉着情况作了检测与分析.这两项检查的阳性率随小鼠月龄增大而升高,在雄鼠高于同龄的雌鼠.然而各组小鼠血清中ANA的阳性率低于肾小球中lg沉着的阳性率.这提示,我们所检测的两项免疫学变化虽然在人和小鼠的SLE病程中经常同时存在,但并不能因此而结论,狼疮性肾炎的表现都是由血清ANA的增加而引起的.

关键词: 抗核因子, 免疫球蛋白类

Abstract: BXSB mice with different ages and both sexes were tested for anti-nuclear antibody (ANA) level in sera and immunoglobuiin (1g) deposits in renal glomeruli. The positive results of two assays increased with the increasing of the age of mice, and those of male mice were higher than in female ones at the same age.

Key words: Antinuclear factors, Immunglobulins