中华皮肤科杂志 ›› 1991, Vol. 24 ›› Issue (4): 228-231.

• 论著 • 上一篇    下一篇

SLE患者PBMC表面的DNA受体及其临床意义

许蓓红, 许德清, 谢彦博   

  1. 中山医科大学孙逸仙纪念医院, 广州, 510120
  • 收稿日期:1989-12-24 修回日期:1990-07-14 出版日期:1991-08-15 发布日期:1991-08-15

DNA receptors on the surface of PBMC and their clinical significance in SLE patients

XU Pei-Hong, XU De-Qing   

  1. Sun Yat-Sen Medical Hospital,Sun Yat-Se Medical University, Guangzhou
  • Received:1989-12-24 Revised:1990-07-14 Online:1991-08-15 Published:1991-08-15

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摘要： 用3H-λDNA进行单点法测定20例SLE患者外周血单个核细胞(PBMC)的DNA受体(DNA-R)的结合量.结果表明SLE患者PRMC表面的ANA-R结合量平均为457.2结合单位/细胞,低于正常人的结合量(14例,平均为715.1结合单位/细胞,P<0.02),当病情加重,其DNA-R结合量便降低(r=-0.6816,P<0.001).病情好转的病人其DNA-R多在正常范围内,与补体检侧对比,表明DNA-R反映SLE病情比CH50和C3更敏感.

Abstract: The binding capacity of DNA-receptor on the surface of peripheral blood mononuclear cells (PBMC) way determined by the method of single point with 3H-lambda phage DNA in 20 SLE pakients. The results showed that the average binding capacity of the DNA-receptor in SLE patients (457.22)was than that in health Individuals (715.1±256, P<0.02).