中华皮肤科杂志 ›› 1989, Vol. 22 ›› Issue (5): 312-313.

• 论著 • 上一篇    下一篇

单纯型遗传性大疱性表皮松解症超微结构的观察

郑和义1, 周光霁1, 张保如1, 路英杰2, 肖玉芳2, 李星奇2   

  1. 1. 中国医学科学院协和医院
  • 收稿日期:1988-03-30 修回日期:1988-09-26 出版日期:1989-10-15 发布日期:1989-10-15

Observation on ultrastructure of hereditary epidermolysis bulle：a simplex

ZHENG He-Yi1, ZHOU Guang-Ji1   

  1. The Peking Union Medicel College Hospital, Beijing
  • Received:1988-03-30 Revised:1988-09-26 Online:1989-10-15 Published:1989-10-15

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摘要： 本文对9例单纯型EB患者的水疱和5例水疱周围外观正常皮肤进行了电镜观察,在电镜下,无论是泛发型还是局限型,初发水疤均位于基底细胞层,主要的超微结构改孪是基底细胞变性溶解,且常发生在基底细胞核下方,张力细丝聚集成块,细胞器结构模糊.外观正常皮肤的超微结构基本正常,作者提出其水疱发病机理可能与基底细胞的张力细丝结构异常有关.

Abstract: In tlus paper, biopsies of fresh blister of 9 patients and adjacent normal-appearance skin of 5 patients were taken for electron microscopy. Whether the patients were generalized or localized type, the initial blister formation was found in the basal layer of the epidermis. Their characteristic ultrastructural changes were basal cell degeneration and cytolysis, especially in the subnuclear area of basal cell, in which clumping and aggregation of tonofilaments were seen, and the structure of organelles was obscure. In normal-appearance skin, the ultrastructure of epidermis was basically normal. It is authors' opinion that the pathogenesis of blister formation may be related to abnormal structure of tonofilaments.