中华皮肤科杂志 ›› 1989, Vol. 22 ›› Issue (3): 167-168.

• 论著 • 上一篇    下一篇

系统性硬皮病皮损胶原纤维的电镜观察

尹旭辉1, 宋芳吉2, 孙国文2, 杨次颖2, 杨景春2   

  1. 1. 沈阳军区后勤部军事医学研究所;
    2. 中国医科大学附属一院皮肤科
  • 收稿日期:1987-12-22 修回日期:1988-06-14 出版日期:1989-06-15 发布日期:1989-06-15

ELECTRON MICROSCOPIC OBSERVATION OF COLLAGEN FIBRILS IN PSS LESIONS

YIN Xu-Hui1, SONG Fang-Ji2   

  1. The First Affiliated Hospital, China Medical University, Shenyang
  • Received:1987-12-22 Revised:1988-06-14 Online:1989-06-15 Published:1989-06-15

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摘要： 本文报告了10例PSS病人皮损组织真皮深层的胶原纤维的透射电镜观察PSS病人的原纤维直径较正常成人的原纤维细(P<0.01),与胎儿的原纤维差异不显著(P>0.05).PSS病人的成纤维细胞富含细胞器和细丝状物质。有一病情迅速进展的病例,标本胶原原纤维粗细明显不等、基质增多。对其中4例PSS病人皮损组织的扫描电镜观察支持上述结果。PSS病人皮损胶原原纤维具有胚胎胶原原纤维的形态学特征,提示为新合成的幼稚胶原。

Abstract: The paper reports the observation on the deep dermis of the skin lesions from 10 patients with PSS by TEM. The collagen fibrils of PSS patients was thinner than that of normal adults (P<0.01), there was no significant difference between the fibrils of PSS patients and those of fetus (P>0.05). The fibroblasts of the PSS patients had plenty of cell organnelle and thin filiform substance. Collagen fibrils in different diameters and increased ground substance were observed in the specimen from a patient with rapid development in a short time. The observation on the skin lesions from 4 patients by SEM supported the above result. The collagen fibrils of the skin lesions from the PSS patients had the morphologic characteristic of the fetus collagen fibrils. It suggests that the fibrils are newly synthesiszed young collagen.