中华皮肤科杂志 ›› 1989, Vol. 22 ›› Issue (3): 169-171.

• 论著 • 上一篇    下一篇

用PAP技术检测红斑狼疮皮损中T淋巴细胞及其亚群

王宝玺1, 袁兆庄1, 蒋大明2   

  1. 1. 北京协和医院皮肤科;
    2. 北京第一传染病医院病理科
  • 收稿日期:1987-12-29 修回日期:1988-07-20 出版日期:1989-06-15 发布日期:1989-06-15

DETE CTION OF T LYMPHOCYTES AND THEIR SUBSETS IN LUPUS LESIONS USING PAP METHOD

WANG Bao-Xi1, YUANG Zhao-Zhuang1   

  1. The Peking Union Medical College Hospital, Beijing
  • Received:1987-12-29 Revised:1988-07-20 Online:1989-06-15 Published:1989-06-15

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摘要： 我们用抗淋巴细胞单克隆抗体过氧化酶-抗过氧化酶(PAP)技术,对6例SLE,4例DLE及2例SCLE患者皮损组织中浸润的T淋巴细胞进行免疫组织化学分析,结果Leu4+细胞占浸润单一核细胞的50~80%,Leu3a+和Leu2a+细胞数占10~60%,且同一组织中两亚群数近似,以Leu3a+细胞稍占优势。这些细胞主要分布在真皮浅层块状浸润区,毛囊或其它皮肤附属器周围,其功能有待于进一步研究探讨。

Abstract: In 12 cases of lupus erythematosus, including 6 cases of systemic lupus erythematosus (SLE), 4 cases of discoid lupus erythematosus (DLE) and 2 cases of subacute cutaneoits lupus erythematosus (SOLE), infiltrating cells of cutaneous lesions were examined using monoclonal antibodies with a peroxidase anti-peroxidase method. It was found that in the infiltrating mononuclear cells, 50~80% cells reacted with Leu4. The percentage of Leu3a and Lcu2a positive cells were 10~60% with approximately equal numbers.