中华皮肤科杂志 ›› 1987, Vol. 20 ›› Issue (2): 86-88.

• 论著 • 上一篇    下一篇

口腔扁平苔藓患者外周血淋巴细胞的染色体显带研究和转化分析

陈作良1, 李辉菶2   

  1. 1. 湖北医学院口腔医院内科;
    2. 湖北医学院口腔医学研究所
  • 收稿日期:1986-03-22 修回日期:1986-06-23 出版日期:1987-04-15 发布日期:1987-04-15

Study on peripheral blood lymphocytes of patients with oral lichen planus by chromosome banding and lymphocyte transformation techniques

Chen Zouliang1   

  • Received:1986-03-22 Revised:1986-06-23 Online:1987-04-15 Published:1987-04-15

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摘要： 通过染色体G显带技术和淋巴细胞转化实验,对18例OLP患者进行了外周血淋巴细胞染色体显带研究,并对其中11例OLP患者同时做了淋巴细胞转化率分析,还选择了一定数量的健康人作本实验的对照.结果发现,OLP患者的染色体结构畸变率明显高于对照组(P<0.01),说明OLP患者染色体稳定性较差,提示OLP有癌变的危险,同时发现OLP患者的2号染色体受累频率最高,其意义不太清楚.淋巴细胞转化率测定的结果,二者无明显差异,其意义在本文中进行了讨论.

Abstract: The chromosomal analysis of cultured peripheral blood lymphocytes from 18 patients with oral lichen planes (OLP) and 20 heaply controls was carried out by G-banding teclmique. The lymphocyte transformation rate was investigated in 11 of the OLP patients and 11 healthy controls. It was found that the structotal aberration rate of chromosome in OLP patients was significantly higher than that of control group (P<0.01). It suggested that the patients' chromosome was unstable snd there might be a risk of malignant transformation in OLP. It was detected that the aberration frequency of No.2 chromosome was the highest in the OLP patients. Its significance was not clear. But no significant difference in lymphocyte transformation rate was found between the two groups.