中华皮肤科杂志 ›› 1987, Vol. 20 ›› Issue (2): 89-91.

• 论著 • 上一篇    下一篇

手足口病Coxsackie A16病毒特异性IgM检测

张鸿源1, 张福明1, 张林2   

  1. 1. 白求恩医科大学地方病研究所;
    2. 白求恩医科大学第一临床学院
  • 收稿日期:1986-04-01 修回日期:1986-07-07 出版日期:1987-04-15 发布日期:1987-04-15

Specific IgM to coxsackie A16 in hand-foot-mouth disease

Zhang Hongyuan1   

  • Received:1986-04-01 Revised:1986-07-07 Online:1987-04-15 Published:1987-04-15

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摘要： 1985年在长春地区发生的16例手足口病患儿的疱疹内容物及血中,有11例分离出CosA16型病毒.16例恢复期血清有12例中和抗体和特异性址G均较急性期增高4倍.而急性期血清经SpA吸收后用免疫酶染色法检测CoaA16型病毒的特异性IgM仍是12例阳性,而健康儿童20份血清中仅有1例阳性.表明该方法作为手足口病早期诊断有实用价值.

Abstract: Coxsackie A 16 viruses were isolated from herpetic liquid and blood of 11 in 16 children with HFMD during 1985 in the district of Changchun. The titers of neutralizing anti-bodies and specific IgG to the virus in 12 sera of 16 sick children during convalescent phase were four times higher than that of the acute phase, the specific IgM to the virus in 12 sera of acute phase was all positive by immunoenzymatic method after SPA absorption, while only one of 20 healthy children gave positive result. It indicates that the method measuring specific IgM can be served for the early diagnosis of HFMD.