中华皮肤科杂志 ›› 1986, Vol. 19 ›› Issue (5): 279-281.

• 论著 • 上一篇    下一篇

“银屑福星”治疗银屑病前后的扫描电镜观察

冯捷1, 徐汉卿1, 王国瑞2, 范明2   

  1. 1. 西安医科大学第二附属医院皮肤科;
    2. 陕西省卫生防疫站电镜室
  • 收稿日期:1985-08-02 修回日期:1986-05-13 出版日期:1986-10-15 发布日期:1986-10-15

SEM observation on psoriasis before and after the treatment with the “Encefusin Tablelts”

Feng Jie1   

  • Received:1985-08-02 Revised:1986-05-13 Online:1986-10-15 Published:1986-10-15

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摘要： 分别于治疗前后用活检法和粘合法取材,对表面细胞进行扫描电镜观察,发现治疗前典型的银屑病亚微结构的特征经过治疗后绝大部分消失,角质细胞恢复常态,呈规则的六角形;间隙变小,连结紧密,排列整齐,细胞表面的陷窝和细胞内表面的微绒毛和微孔消失或绝大部分消失.经统计学处理,治疗前后有非常显著性差异.表明“银屑福星”有恢复细胞表面膜的糖蛋白,增加细胞粘着性,使细胞间丧失的接触抑制生长的能力得以恢复,使细胞分裂活性作用达正常状态.

Abstract: In order to determine whether the "Encefusin Tablets" has the therapeutic effect objectively. Authors observed the ultrastructural marks on the surface of the horny cells as the objective criteria. Biopsy specimens were taken from the lesion and normal skin of five patients with psoriasis before and after the treatment with the drug, and observed under SEM. Before treatment there were many micropits and microvilli on the inner surface of the horny cells of typical psoriatic lesion. But after treatment the micropits disappeared and the number of the microvilli on the cell membrane of horny cells decreased significantly after treatment (P<0.001). The above data indicate that "Encefusin Tablets" have good effect on the recovery of glucoprotein on the horny cell membrane and can strengthen the adhesion between horny cells.