中华皮肤科杂志 ›› 1986, Vol. 19 ›› Issue (5): 276-278.

• 论著 • 上一篇    下一篇

Job综合征(附一例报告与电镜观察)

薛筑云1, 汤意诚1, 郁辉1, 郑乐1, 程宝庚2   

  1. 1. 南京医学院一附院皮肤科;
    2. 南京医学院电镜室
  • 收稿日期:1985-12-11 修回日期:1986-03-18 出版日期:1986-10-15 发布日期:1986-10-15

Observation on Job’s syndrome by electron microscopy

Xue Zhuyun1   

  • Received:1985-12-11 Revised:1986-03-18 Online:1986-10-15 Published:1986-10-15

PDF (PC)

367

赞

摘要： 报告一例Job综合征,男性,5岁.特点是婴儿期发病,皮肤复发性“冷”葡萄球菌脓肿,皮肤一肺部反复细菌感染,血清IgE显著增高,伴发湿疹,面容粗糙、关节过伸、缺髓骨、嗜酸性白细胞轻度增高.嗜中性粒细胞吞噬功能和N,B,T正常.皮肤组织病理示肉芽肿性炎症浸润,骨髓透射电镜检查示中性粒细胞结构改变.结合本例对本病作了文献复习和讨论.

Abstract: A 5-year-old boy with Job's syndrome was reported. Major clinical features of the patient included "cold" and recurrent staphylococcal abscesses, recurrent infection of skin and lung, markedly elevated serum IgE values, eczema, "lion" face, hyperextensible joints, absence of patella, slightly elevated eosinophilic cells, normal neutrophil phagocytic activity and normal N. B. T. Histological features of the skin lesion showed gronulomatous inflammatory infiltration. Transmission electron microscopy of the bone marrow showed changes of the neutrophilic cell structure.