中华皮肤科杂志 ›› 1983, Vol. 16 ›› Issue (1): 19-23.

• 论著 • 上一篇    下一篇

麻风病的治疗研究Ⅵ异丁基呱嗪力复霉素(R-76-1)的疗效观察

上海遵义医院1, 福建莆田县皮肤病防治院2, 福建省皮肤病防治院3, 福建龙溪地区皮肤病防治院4   

  1. 1. 上海遵义医院;
    2. 福建莆田县皮肤病防治院;
    3. 福建省皮肤病防治院;
    4. 福建龙溪地区皮肤病防治院
  • 出版日期:1983-03-15 发布日期:1983-03-15

Therapeutic study inleprosy：Ⅵ. Observation of the therapeutic effect of isobutyl piperazinyl refamycin

Shanghai Zunyi Hospital1   

  • Online:1983-03-15 Published:1983-03-15

PDF (PC)

258

赞

摘要： 19例LL或BL型麻风用异丁基呱嚓力复霉素(R-76-1)150毫克/日治疗6~18月.临床细菌和病理组毕检查都显示有肯定的疗效.最初8个月的疗效比以后显著,导致这种现象的原因不明.10例患者在R-76-1治疗前后连续自皮损取材接种小鼠足垫以探讨治疗后菌株对小鼠足垫感染能力的变化,R-76-1治疗前的标本尚用小鼠足垫接种法验证菌株对药物的敏感性,10例患者中7例对氨苯飒高度耐药、1例对硫脉类药物耐药.R-76-1治疗后10例患者的菌株对小鼠足垫丧失感染能力估计时间的中位数是7.25天.表明即使小济量R-76-1对麻风菌也有快速的杀菌作用,对耐氨苯砜或硫脲类药物的菌株也不例外.初步认为R-76-1是一种比较安全的药物,.其麻风反应诱发率和副作用并不超过利福平.尚需进户步通临床实践对比R-761与利福平的疗效.

Abstract: Nineteen multibacillary (LL or BL type) leprosy patients were treated with Isobutylpiperazinyl rifamycin(R-76-1)150 mg daily for 6 to 18 months with a definite therapeutic effect as shown by the clinical assessments, skin, smears and histologic studies. Tlie improvement was more marked daring the first 6-month period than the second and third 6-month periods-with unknown reason.Mouse foot pad inoculation with serial skin biopsy specimens had been obtained from 10 patients of this group.