中华皮肤科杂志 ›› 1982, Vol. 15 ›› Issue (2): 67-71.

• 论著 •    下一篇

抗双链DNA抗体与系统性红斑性狼疮——马疫锥虫血片免疫荧光法和Farr氏放射免疫法之比较

徐世正, 王慧珍, 李洪迥   

  1. 中国医学科学院、首都医院
  • 出版日期:1982-06-15 发布日期:1982-06-15

Anti-ds-DNA antibody and systemic lupus erythematosus：A comparison of trypanosoma equiperdum blood smear immunofluorescent method and Farr’s immunoradioassay

Xu Shizheng   

  • Online:1982-06-15 Published:1982-06-15

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摘要： 用马疫锥虫血片免疫荧光法(TE-IF法)和Farr氏放射免疫法测定了453例(包括系统性红斑性狼疮98例,其它结缔组织疾病165例.非结缔组织疾病61例及健康对照129例)血清抗双链DNA抗体.结果表明.抗欢链DNA抗体是SLE特异的抗体,其特异性程度因方法而异:通过比较.TE-IF法比Farr氏法更特异.无假阳性反应,而且操作简便.结果稳定可靠.可用于SLE的诊断和追踪.

Abstract: Sera from 453 persons, including 98 patients with systemic lupus erythematosus(SLE), 165 patieats with other connective tissue diseases sad 61 miscellaneous diseases as well as 129 normal control. were determined by two methods-Trypanosoma Equiperdum immunofluorescent(TE-IF)method and Farr immunoprecipitatioa assay for anti-double stranded DNA antibodies. The results showed that antidsDNA antibodies are highly specific for SLE. The specificity is influenced, by differeat methods. In comparison with Farr assay, the TE-IF method is better not-oaly is specificity but also in simplicity of performance,reliability, constancy of results and abseace of falsepositive reactions. It is of value in-diagnosisrand follow-up of SLE.