以氨苯砜综合征为模型解析药物超敏反应中的免疫失衡

doi:10.35541/cjd.20260100

中华皮肤科杂志 ›› 2026, Vol. 59 ›› Issue (9): 844-849.doi: 10.35541/cjd.20260100

• 专家论坛·免疫介导炎症性皮肤病 • 上一篇下一篇

以氨苯砜综合征为模型解析药物超敏反应中的免疫失衡

赵晴孙乐乐敖穗婷翟于凡刘红张福仁

山东第一医科大学附属皮肤病医院山东省皮肤病性病防治研究所，济南 250022

收稿日期:2026-02-26 修回日期:2026-07-28 发布日期:2026-09-03
通讯作者: 张福仁 E-mail:zhangfuren@hotmail.com
基金资助:
国家自然科学基金（82573985）

Analysis of immune dysregulation in drug hypersensitivity by using dapsone hypersensitivity syndrome as a model

Zhao Qing, Sun Lele, Ao Suiting, Zhai Yufan, Liu Hong, Zhang Furen

Dermatology Hospital of Shandong First Medical University, Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China

Received:2026-02-26 Revised:2026-07-28 Published:2026-09-03
Contact: Zhang Furen E-mail:zhangfuren@hotmail.com
Supported by:
National Natural Science Foundation of China（82573985）

摘要/Abstract

摘要： 【摘要】药物超敏反应是一种潜伏期长、临床表现复杂、可威胁生命的严重药物不良反应。本文以氨苯砜综合征为模型，深入剖析遗传、固有免疫及获得性免疫在药物超敏反应发生中的作用。基于此模型，提出当前药物超敏反应研究领域在预防、诊断、治疗中亟待解决的问题，并前瞻性地提出通过构建一个多因素风险预测模型，预防药物超敏反应的发生。

Abstract: 【Abstract】 Drug hypersensitivity is a severe adverse drug reaction characterized by a prolonged latency period, complex clinical manifestations, and a potentially life-threatening course. In this article, dapsone hypersensitivity syndrome serves as a model for dissecting the roles of genetic predisposition, innate immunity, and acquired immunity in the development of drug hypersensitivity. Based on this model, key unresolved challenges in the prevention, diagnosis, and treatment of drug hypersensitivity are proposed, and a multifactorial risk prediction model is expected to be established to guide the prevention of drug hypersensitivity.

Key words: Drug-related side effects and adverse reactions, Hypersensitivity, delayed, Dapsone, Dapsone hypersensitivity syndrome, Pharmacogenomic testing, Killer cells, natural, Tumor necrosis factor-alpha, Precision medicine

赵晴孙乐乐敖穗婷翟于凡刘红张福仁. 以氨苯砜综合征为模型解析药物超敏反应中的免疫失衡[J]. 中华皮肤科杂志, 2026,59(9):844-849. doi:10.35541/cjd.20260100

Zhao Qing, Sun Lele, Ao Suiting, Zhai Yufan, Liu Hong, Zhang Furen. Analysis of immune dysregulation in drug hypersensitivity by using dapsone hypersensitivity syndrome as a model[J]. Chinese Journal of Dermatology, 2026, 59(9): 844-849.doi:10.35541/cjd.20260100

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以氨苯砜综合征为模型解析药物超敏反应中的免疫失衡

Analysis of immune dysregulation in drug hypersensitivity by using dapsone hypersensitivity syndrome as a model

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