中华皮肤科杂志 ›› 2020, Vol. 53 ›› Issue (3): 233-235.doi: 10.35541/cjd.20180715

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普瑞巴林在皮肤科的应用进展

向睿宇    李锁    冯素英   

  1. 中国医学科学院  北京协和医学院  皮肤病医院皮肤科  江苏省皮肤病与性病学重点实验室,南京  210042
  • 收稿日期:2018-08-24 修回日期:2019-03-25 发布日期:2020-03-03
  • 通讯作者: 冯素英 E-mail:fengsuying@medmail.com.cn
  • 基金资助:
    中国医学科学院医学与健康科技创新工程项目(CIFMS-2017-I2M-1-017)

Application of pregabalin in dermatology

Xiang Ruiyu, Li Suo, Feng Suying   

  1. Department of Dermatology, Hospital for Skin Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing 210042, China
  • Received:2018-08-24 Revised:2019-03-25 Published:2020-03-03
  • Contact: Feng Suying E-mail:fengsuying@medmail.com.cn
  • Supported by:
    CAMS Innovation Fund for Medical Sciences(CIFMS-2017-I2M-1-017)

摘要: 【摘要】 普瑞巴林作用于神经系统电压门控钙通道,可减少多种神经递质的释放。目前广泛应用于多种疾病包括神经性疼痛、广泛性焦虑症、癫痫等的治疗。在皮肤科,普瑞巴林对带状疱疹后遗神经痛、结节性痒疹、尿毒症性瘙痒、神经相关瘙痒、精神相关瘙痒等也有治疗作用。

关键词: GABA拮抗剂; 治疗; 瘙痒症; 神经痛, 带状疱疹后; 皮肤疾病; 普瑞巴林

Abstract: 【Abstract】 Pregabalin can reduce the release of multiple neurotransmitters by acting on the voltage?gated calcium channel of the nervous system. It is currently widely used in a variety of diseases, including neuropathic pain, generalized anxiety disorder, epilepsy and so on. In dermatology department, pregabalin also has a therapeutic effect on postherpetic neuralgia, prurigo nodularis, uremic pruritus, nerve?related pruritus and mentally relevant pruritus.

Key words: GABA antagonists, Therapy, Pruritus, Neuralgia, postherpetic, Skin diseases, Pregabalin