胰岛素样生长因子1受体信号通路在相关皮肤病发病机制中的作用

doi:10.35541/cjd.20180712

中华皮肤科杂志 ›› 2019, Vol. 52 ›› Issue (12): 934-936.doi: 10.35541/cjd.20180712

胰岛素样生长因子1受体信号通路在相关皮肤病发病机制中的作用

汤红燕¹ 肖斌² 杨桂兰³

¹兰州大学第二医院皮肤科 730000；²江苏省常熟市第五人民医院皮肤科 215500；³南方医科大学深圳医院皮肤美容与性病科 518000

收稿日期:2018-08-23 修回日期:2019-08-09 发布日期:2019-12-02
通讯作者: 杨桂兰 E-mail:drgly2006@126.com
基金资助:
皮肤病学教育部重点实验室（复旦大学皮肤病研究所-华山医院）开放课题基金（HS2017-1-003）

Role of the insulin-like growth factor 1 receptor signaling pathway in the pathogenesis of related skin diseases

Tang Hongyan¹, Xiao Bin², Yang Guilan³

¹Department of Dermatology, Lanzhou University Second Hospital, Lanzhou 730000, China; ²Department of Dermatology, Changshu No.5 People′s Hospital, Changshu 215500, Jiangsu, China; ³Department of Cosmetic Dermatology and Venereology, Shenzhen Hospital of Southern Medical University, Shenzhen 518000, China

Received:2018-08-23 Revised:2019-08-09 Published:2019-12-02
Contact: Yang Guilan E-mail:drgly2006@126.com
Supported by:
Open Research Fund of Ministry of Education Key Laboratory of Dermatology （Fudan University Institute of Dermatology-Huashan Hospital）（HS2017-1-003）

摘要/Abstract

摘要： 【摘要】胰岛素样生长因子（IGF）与靶组织细胞表面IGF1受体（IGF1R）特异性结合后可调节细胞凋亡、增殖、衰老等生理过程，与机体生长发育、疾病发生、发展密切相关。IGF1与IGF1Rα结合后可引起IGF1Rβ亚基构象改变，进而活化受体酪氨酸激酶，启动下游磷脂酰肌醇3激酶通路和丝裂原活化蛋白激酶通路，参与痤疮、银屑病等皮肤病的发病。本文综述IGF1R信号通路在相关皮肤病发病机制中的研究进展。

关键词: 胰岛素样生长因子Ⅰ, 磷酸肌醇3-激酶类, MAP激酶信号系统, 皮肤疾病

Abstract: 【Abstract】 After binding to the specific insulin-like growth factor 1 receptor （IGF1R） on the surface of target tissue cells, IGF can regulate physiological processes such as apoptosis, proliferation and senescence, which are closely related to growth and development of the body, and occurrence and development of diseases. The binding between IGF1 and IGF1Rα can cause conformational changes of the beta subunit of IGF1R, lead to activation of receptor tyrosine kinase, initiation of the downstream phosphatidylinositol 3-kinase pathway and mitogen-activated protein kinase pathway, and finally participate in the occurrence of acne, psoriasis and other skin diseases. This review summarizes research advances in the role of the IGF1R signaling pathway in the pathogenesis of related skin diseases.

Key words: Insulin-like growth factorⅠ, Phosphatidylinositol 3-kinases, MAP kinase signaling system, Skin diseases

汤红燕肖斌杨桂兰. 胰岛素样生长因子1受体信号通路在相关皮肤病发病机制中的作用[J]. 中华皮肤科杂志, 2019,52(12):934-936. doi:10.35541/cjd.20180712

Tang Hongyan, Xiao Bin, Yang Guilan. Role of the insulin-like growth factor 1 receptor signaling pathway in the pathogenesis of related skin diseases[J]. Chinese Journal of Dermatology, 2019, 52(12): 934-936.doi:10.35541/cjd.20180712

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胰岛素样生长因子1受体信号通路在相关皮肤病发病机制中的作用

Role of the insulin-like growth factor 1 receptor signaling pathway in the pathogenesis of related skin diseases

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