Abstract: Serum levels of zinc in 120 healthy persons, 40 patients with acne vulgaris, 30 with alopecia seborrheica, 37 with psoriasis, and 11 with vitiligo in Shenyang district were determined with atomic absorption spectrometer, The results showed that only the seruim level of zinc in alopecia seborrheica group was significantly lower(p<0.05)than that of healthy persons, while the difference between other patienta groups and healthy persons was not significant These patient were treated with zinc sulfate the clinicala response were as follows:marked improvement for acne vnlgaris, some degree of improvement for alopecia seborrheica, and no improvement for psoriasis and vitiligo.