Abstract: The method of sensitization of normal lymphocytes with scale extract from patients with psoriasis,the procedure for the preparation of transfer factor and its application in the treatment of psoriasis are presented in this article.40 cases of psoriasis were treated with this method and 90% of the cases so treated showed effective therapeutic results.Observations on immunological functions performed before treatment revealed that the ERFC and LTT values were low,The ERFC and LTT values increased significantly after treatment.The anthers concluded that injections of specific transfer factor could activate the immunological functions of macrophages and elevate immunological reactivities which resulted in good therapeutic effects.