Abstract: Zinc ion is one of the very important trace elements in mankind,aad is responsible for some very important biological actiyities.In order to study the relationship between skin diseases and serum zinc concentrations,serum levels of zinc in 200 cases of psoriasis,acne vulgaris,vitiligo,pityriasis rubra pilaris,keratoerythrodermia symmetrica progressiva(KSP),anaphylactic purpura and melanosis and in 65 healthy individuals as control were recorded by atomic absorption spectrometric method.The mean values of zinc in each group were treated statistically.