Abstract: Objectives To investigate the role of laminin (LM) and fibronectin (FN) in the growth cycle of human hair follicles.Methods The expression of LM and FN was detected by streptavidin-peroxidase (SP) staining.Results In the anagen phase,LM was expressed in dermal papilla,basement membrane and outer root sheath;FN was expressed in dermal papilla,basement membrane and connective tissue sheath.In the catagen phase,LM showed a lower expression in the dermal papilla and a linear expression in the basement membrane;the expression of FN in the dermal papilla and basement membrane was less intense than that in anagen phase,but was still positive.In the telogen phase,LM was only expressed in the basement membrane while FN was negative.Conclusion The difference between LM and FN expression in hair growth cycle indicates that LM and FN may play important roles in the regulation of human hair follicle growth cycl.

Key words: Hair follicle, Laminin, Fibronectins