Abstract:

Objective To investigate the role of the expression of p27 and cyclin E in the pathogenesis of Bowen's disease and squamous cell carcinoma (SCC).Methods The expression of p27 and cyclin E was assessed by immunohistochemical method in 16 patients with Bowen's disease,53 patients with SCC and 25 normal controls.Results The expression of p27 was lower in Bowen's disease and SCC compared to that in the normal skin,and the expression level decreased with a decline in the differentiation of tumors,i.e.the lowest expression was observed in poorly differentiated SCC,followed by highly differentiated SCC and Bowen's disease.The expression of cyclin E was higher in Bowen's disease and SCC than that in the normal skin,and the expression level increased with a decline in the differentiation of tumors.The expression of p27 was inversely correlated with that of cyclin E among all the cases of Bowen's disease and SCC.Conclusion The abnormal expression of p27 and cyclin E may contribute to the pathogenesis of Bowen's disease and SCC.

Key words: Bowen’s disease, Carcinoma,squamous cell, Cyclin E, p27