暗娼人群DC-SIGN及DC-SIGNR基因多态性初步研究

Abstract

Abstract: Objective To determine the genetic polymorphisms of DC-SIGN and DC-SIGNR among HIV negative Chinese female sex workers.Methods The 69 bp tandem repeat numbers in exon 4 of the DC-SIGN and DC-SIGNR were examined by PCR in 234 HIV-1-seronegative female commercial sex workers.Results It was found that 4 of 234 individuals were heterozygous in DC-SIGN.For DC-SIGNR,the allele frequencies were seven times repeated in 65.2%,5 in 18.4%,and 9 in 11.9%.Those patterns of alleles frequencies were significantly different compared with those reported in the Caucasians residing in Europe.Conclusion Polymorphisms of DC-SIGN repeat region seem to be infrequent in Chinese female sex workers and those of DC-SIGNR are different from what reported in other races.

Key words: DC-SIGN, DC-SIGNR, Polymorphism, genetic, Female sex worker

WANG Feng, HONG Fu-chang, WANG Hui, LAN Li-na, Chunhui Wang, XIONG Li-kuan, XIAO Xin, ZHOU Bo-ping, ZHOU Hua, Tuofu Zhu. The genetic polymorphisms of DC-SIGN and DC-SIGNR among female sex workers[J].Chinese Journal of Dermatology, 2006, 39(11): 645-647.

References

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The genetic polymorphisms of DC-SIGN and DC-SIGNR among female sex workers

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